The Function of MMP16
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Protein names
Recommended name:
Matrix metalloproteinase-16Short name:
MMP-16Alternative name(s):
MMP-X2Membrane-type matrix metalloproteinase 3
MT-MMP 3
MTMMP3
Membrane-type-3 matrix metalloproteinase
MT3-MMP
MT3MMP
- RS36116061 (MMP16) ??
- RS58605417 (MMP16) ??
- RS6981717 (MMP16) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase MMP16
| Substances | Interaction | Organism | Category |
Substances That Decrease MMP16
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
Developmental stage:
Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
Enzyme Regulation:
TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
- Calcium Ion Binding
- Enzyme Activator Activity
- Metalloaminopeptidase Activity
- Metalloendopeptidase Activity
- Zinc Ion Binding
Biological Processes:
- Chondrocyte Proliferation
- Collagen Catabolic Process
- Craniofacial Suture Morphogenesis
- Embryonic Cranial Skeleton Morphogenesis
- Endochondral Ossification
- Extracellular Matrix Disassembly
- Protein Metabolic Process
- Protein Processing
- Proteolysis