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  3. MMP16

MMP16 (Matrix metallopeptidase 16)

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The Function of MMP16

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

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Protein names

Recommended name:

Matrix metalloproteinase-16

Short name:

MMP-16

Alternative name(s):

MMP-X2
Membrane-type matrix metalloproteinase 3
MT-MMP 3
MTMMP3
Membrane-type-3 matrix metalloproteinase
MT3-MMP
MT3MMP

MMP16 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS36116061 (MMP16) ??
  2. RS58605417 (MMP16) ??
  3. RS6981717 (MMP16) ??

Top Gene-Substance Interactions

Substances That Increase MMP16

Substances Interaction Organism Category

Substances That Decrease MMP16

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Developmental stage:

Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.

Enzyme Regulation:

TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Calcium Ion Binding
  • Enzyme Activator Activity
  • Metalloaminopeptidase Activity
  • Metalloendopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Chondrocyte Proliferation
  • Collagen Catabolic Process
  • Craniofacial Suture Morphogenesis
  • Embryonic Cranial Skeleton Morphogenesis
  • Endochondral Ossification
  • Extracellular Matrix Disassembly
  • Protein Metabolic Process
  • Protein Processing
  • Proteolysis

Drug Bank:

  • Marimastat
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| stromelysin-3| membrane-type matrix metalloproteinase| AS27_10531| AS28_09228| C8orf57| CB1_002519032| D623_10016685| GW7_17474| H920_15571| I79_014551| M91_21428| matrix metallopeptidase 16 (membrane-inserted)| matrix metalloproteinase 16| matrix metalloproteinase-16| matrix metalloproteinase 16 isoform 1-like protein| matrix metalloproteinase 16 (membrane-inserted)| MDA_GLEAN10007260| membrane type-3 matrix metalloproteinase| membrane-type-3 matrix metalloproteinase| Membrane-type 3 matrix metalloproteinase| Membrane type 3-MMP| membrane type-matrix metalloproteinase| membrane type matrix metalloproteinase 16| membrane-type matrix metalloproteinase 3| MMP-16| MMP-X2| MT3MMP| MT3-MMP| MT-MMP2| MTMMP3| MT-MMP3| MT-MMP 3| N301_02663| N303_06396| N305_11244| N306_07990| N307_11053| N308_11834| N309_12225| N311_01187| N322_12088| N332_03092| N334_12315| N336_05181| N339_06465| olmt3-mmp| PAL_GLEAN10019463| PANDA_007683| Putative transmembrane protein C8orf57| UY3_00437| Y1Q_028209| Z169_11089| mmp16

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