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  3. MMP15

MMP15 (Matrix metallopeptidase 15)

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The Function of MMP15

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

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Protein names

Recommended name:

Matrix metalloproteinase-15

Short name:

MMP-15

Alternative name(s):

Membrane-type matrix metalloproteinase 2
MT-MMP 2
MTMMP2
Membrane-type-2 matrix metalloproteinase
MT2-MMP
MT2MMP
SMCP-2

MMP15 SNPs

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  1. RS12447804 (MMP15) ??

Top Gene-Substance Interactions

Substances That Increase MMP15

Substances Interaction Organism Category

Substances That Decrease MMP15

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Fos

Tissue specificity:

Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

Gene Pathways:

  • Extracellular matrix organization

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Calcium Ion Binding
  • Enzyme Activator Activity
  • Metalloaminopeptidase Activity
  • Metalloendopeptidase Activity
  • Serine-Type Endopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Cellular Protein Modification Process
  • Collagen Catabolic Process
  • Endodermal Cell Differentiation
  • Extracellular Matrix Disassembly
  • Proteolysis
  • Response To Estradiol

Drug Bank:

  • Marimastat
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SMCP-2| A306_12809| AS27_01793| AS28_12824| CB1_000445005| M91_00071| M959_08891| matrix metallopeptidase 15 (membrane-inserted)| matrix metallopeptidase 15 (membrane-inserted) isoform A| matrix metallopeptidase 15 (membrane-inserted) isoform B| Matrix metalloproteinase-14| matrix metalloproteinase 15| matrix metalloproteinase-15| matrix metalloproteinase-15-like protein| matrix metalloproteinase 15 (membrane-inserted)| matrix metalloproteinase-15 preproprotein| Matrix metalloproteinase-16| MDA_GLEAN10014283| membrane-type-2 matrix metalloproteinase| Membrane type 2-MMP| membrane-type matrix metalloproteinase| membrane-type matrix metalloproteinase 2| MMP-15| MT2MMP| MT2-MMP| MTMMP2| MT-MMP 2| N300_13438| N301_13815| N302_06932| N303_10094| N305_06510| N306_05611| N307_02917| N308_00527| N309_09759| N310_05329| N312_05929| N322_07508| N326_04238| N330_07406| N331_09983| N332_07370| N333_05610| N339_10454| N340_09786| N341_07367| olmt2-mmp| PAL_GLEAN10011108| PANDA_000051| Y1Q_015922| Y956_09204| Z169_06139| mmp15

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