The Function of MMP15
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
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Protein names
Recommended name:
Matrix metalloproteinase-15Short name:
MMP-15Alternative name(s):
Membrane-type matrix metalloproteinase 2MT-MMP 2
MTMMP2
Membrane-type-2 matrix metalloproteinase
MT2-MMP
MT2MMP
SMCP-2
- RS12447804 (MMP15) ??
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Top Gene-Substance Interactions
Substances That Increase MMP15
| Substances | Interaction | Organism | Category |
Substances That Decrease MMP15
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
Gene Pathways:
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
- Metalloendopeptidase Activity
- Serine-Type Endopeptidase Activity
- Calcium Ion Binding
- Enzyme Activator Activity
- Zinc Ion Binding
- Metalloaminopeptidase Activity
Biological Processes:
- Cellular Protein Modification Process
- Proteolysis
- Extracellular Matrix Disassembly
- Collagen Catabolic Process
- Response To Estradiol
- Endodermal Cell Differentiation