The Function of MMP15
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Matrix metalloproteinase-15Short name:
MMP-15Alternative name(s):
Membrane-type matrix metalloproteinase 2MT-MMP 2
MTMMP2
Membrane-type-2 matrix metalloproteinase
MT2-MMP
MT2MMP
SMCP-2
- RS12447804 (MMP15) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase MMP15
Substances | Interaction | Organism | Category |
Substances That Decrease MMP15
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.
Gene Pathways:
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
- Calcium Ion Binding
- Enzyme Activator Activity
- Metalloaminopeptidase Activity
- Metalloendopeptidase Activity
- Serine-Type Endopeptidase Activity
- Zinc Ion Binding
Biological Processes:
- Cellular Protein Modification Process
- Collagen Catabolic Process
- Endodermal Cell Differentiation
- Extracellular Matrix Disassembly
- Proteolysis
- Response To Estradiol