Summary of MMP12
MMP12 (matrix metallopeptidase 12) encodes a protein that, when mature, degrades the elastin between cells, as part of normal developement. Muations in this gene have been implicated in Chronic Obstructive Pulmonary Disease and aneurysm formation. [R]
The Function of MMP12
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Protein names
Recommended name:
Macrophage metalloelastaseShort name:
MEAlternative name(s):
MMEMacrophage elastase
hME
Matrix metalloproteinase-12
MMP-12
- RS12808148 (MMP12) ??
- RS17368582 (MMP12) ??
- RS17368659 (MMP12) ??
- RS573521 (MMP12) ??
- RS608194 (MMP12) ??
- RS626750 (MMP12) ??
- RS652438 (MMP12) ??
- RS654600 (MMP12) ??
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Top Gene-Substance Interactions
MMP12 Interacts with These Diseases
| Disease | Score |
Substances That Increase MMP12
| Substances | Interaction | Organism | Category |
Substances That Decrease MMP12
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Found in alveolar macrophages but not in peripheral blood monocytes.
Gene Pathways:
Induction:
By exposure to bacterial lipopolysaccharides (LPS). Inhibited by dexamethasone.
Cofactor:
Binds 2 Zn(2+) ions per subunit.
Molecular Function:
- Endopeptidase Activity
- Metalloendopeptidase Activity
- Serine-Type Endopeptidase Activity
- Calcium Ion Binding
- Zinc Ion Binding
Biological Processes:
- Proteolysis
- Response To Organic Cyclic Compound
- Extracellular Matrix Disassembly
- Collagen Catabolic Process
- Wound Healing, Spreading Of Epidermal Cells
- Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing