• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. MMP12

MMP12 (Matrix metallopeptidase 12)

Loading...

Summary of MMP12

MMP12 (matrix metallopeptidase 12) encodes a protein that, when mature, degrades the elastin between cells, as part of normal developement. Muations in this gene have been implicated in Chronic Obstructive Pulmonary Disease and aneurysm formation.  [R]

0 users want this gene increased, 0 users want it decreased

The Function of MMP12

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

Protein names

Recommended name:

Macrophage metalloelastase

Short name:

ME

Alternative name(s):

MME
Macrophage elastase
hME
Matrix metalloproteinase-12
MMP-12

MMP12 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12808148 (MMP12) ??
  2. RS17368582 (MMP12) ??
  3. RS17368659 (MMP12) ??
  4. RS573521 (MMP12) ??
  5. RS608194 (MMP12) ??
  6. RS626750 (MMP12) ??
  7. RS652438 (MMP12) ??
  8. RS654600 (MMP12) ??

Top Gene-Substance Interactions

MMP12 Interacts with These Diseases

Disease Score

Substances That Increase MMP12

Substances Interaction Organism Category

Substances That Decrease MMP12

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1
  • STAT5A
  • c-Fos
  • GATA-3

Tissue specificity:

Found in alveolar macrophages but not in peripheral blood monocytes.

Gene Pathways:

  • Extracellular matrix organization

Induction:

By exposure to bacterial lipopolysaccharides (LPS). Inhibited by dexamethasone.

Cofactor:

Binds 2 Zn(2+) ions per subunit.

Molecular Function:

  • Calcium Ion Binding
  • Endopeptidase Activity
  • Metalloendopeptidase Activity
  • Serine-Type Endopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Collagen Catabolic Process
  • Extracellular Matrix Disassembly
  • Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
  • Proteolysis
  • Wound Healing, Spreading Of Epidermal Cells
  • Response To Organic Cyclic Compound

Drug Bank:

  • Acetohydroxamic Acid
  • Marimastat
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AV378681| CB1_000877047| H920_12975| HME| M91_17716| macrophage elastase| macrophage metalloelastase| macrophage metalloelastase MMP-12| macrophage metalloelastase preproprotein| matrix metallopeptidase 12-like protein| matrix metallopeptidase 12 (macrophage elastase)| matrix metalloproteinase 12| matrix metalloproteinase-12| matrix metalloproteinase 12 (macrophage elastase)| ME| MME| Mmel| MMP-12| PAL_GLEAN10013824| PANDA_011007| TREES_T100006572| mmp12

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved