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  3. MMP1

MMP1 (Matrix metallopeptidase 1)

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Summary of MMP1

MMP1 (matrix Mettalopeptidase 1) codes for a protein that, when mature, breaks down intercellular collagen as a part of normal development. Mutations in this gene contribute to Chronic obrstructive pulmonary disease (COPD), skin aging, and bladder cancer. [R] 

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The Function of MMP1

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

Protein names

Recommended name:

Interstitial collagenase

Short name:

MMP-1

Alternative name(s):

Fibroblast collagenase
Matrix metalloproteinase-1

MMP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10488 (MMP1) ??
  2. RS514921 (MMP1) ??
  3. RS5854 (MMP1) ??

Top Gene-Substance Interactions

MMP1 Interacts with These Diseases

Disease Score

Substances That Increase MMP1

Substances Interaction Organism Category

Substances That Decrease MMP1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Recessive dystrophic epidermolysis bullosaChronic obstructive pulmonary disease

     From NCBI Gene: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] From UniProt: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • c-Jun
  • STAT3
  • NF-kappaB1
  • c-Fos
  • Fra-1

Gene Pathways:

  • Pathways in cancer
  • PPAR signaling pathway
  • Metabolism of proteins
  • Hemostasis
  • Extracellular matrix organization
  • Bladder cancer
  • Rheumatoid arthritis

Enzyme Regulation:

Can be activated without removal of the activation peptide.

Cofactor:

Binds 2 Zn(2+) ions per subunit.

Molecular Function:

  • Calcium Ion Binding
  • Endopeptidase Activity
  • Metalloendopeptidase Activity
  • Serine-Type Endopeptidase Activity
  • Zinc Ion Binding

Biological Processes:

  • Cellular Protein Metabolic Process
  • Collagen Catabolic Process
  • Extracellular Matrix Disassembly
  • Leukocyte Migration
  • Positive Regulation Of Protein Oligomerization
  • Proteolysis
  • Viral Process

Drug Bank:

  • Marimastat
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_000877049| CG4859 gene product from transcript CG4859-RI| CG4859-PC| CG4859-PD| CG4859-PE| CG4859-PF| CG4859-PG| CG4859-PH| CG4859-PI| CG4859-PJ| CG4859-PK| CG4859-PL| clg| CLGN| col4| collagenase-1| collagenase-4| dm1-MMP| Dmel_CG4859| dMMP1| fibroblast collagenase| H920_12973| Interstitial collagenase| interstitial collagenase A| interstitial collagenase isoform 1 preproprotein| interstitial collagenase-like| Interstitial collagenase-like protein| matix metalloproteinase I collagenase propeptide| matrix metallopeptidase 1a (interstitial collagenase)| matrix metallopeptidase 1 (interstitial collagenase)| matrix metalloprotease| matrix metalloprotease 1| matrix metalloproteinase1| matrix metalloproteinase 1| matrix metalloproteinase-1| matrix metalloproteinase 1a (interstitial collagenase)| matrix metalloproteinase 1 (type I collagenase)| matrix metalloprotinase 1| metalloproteinase| Mmp 1| MMP-1| MMP-18| Mmp1a| Mmp1-PC| Mmp1-PD| Mmp1-PE| Mmp1-PF| Mmp1-PG| Mmp1-PH| Mmp1-PI| Mmp1-PJ| Mmp1-PK| Mmp1-PL| MMP8| myocardial collagenase| PAL_GLEAN10013822| TREES_T100006574| xcol4| mmp1

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