From NCBI Gene: Recessive dystrophic epidermolysis bullosaChronic obstructive pulmonary disease

     From NCBI Gene: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] From UniProt: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

The following transcription factors affect gene expression:

• NF-kappaB
• p53
• AP-1
• c-Jun
• STAT3
• NF-kappaB1
• c-Fos
• Fra-1

Enzyme Regulation:

Can be activated without removal of the activation peptide.

Cofactor:

Binds 2 Zn(2+) ions per subunit.

Molecular Function:

• Calcium Ion Binding
• Endopeptidase Activity
• Metalloendopeptidase Activity
• Serine-Type Endopeptidase Activity
• Zinc Ion Binding

Biological Processes:

• Cellular Protein Metabolic Process
• Collagen Catabolic Process
• Extracellular Matrix Disassembly
• Leukocyte Migration
• Positive Regulation Of Protein Oligomerization
• Proteolysis
• Viral Process

Drug Bank:

• Marimastat