Summary of MMP1
MMP1 (matrix Mettalopeptidase 1) codes for a protein that, when mature, breaks down intercellular collagen as a part of normal development. Mutations in this gene contribute to Chronic obrstructive pulmonary disease (COPD), skin aging, and bladder cancer. [R]
The Function of MMP1
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Protein names
Recommended name:
Interstitial collagenaseShort name:
MMP-1Alternative name(s):
Fibroblast collagenaseMatrix metalloproteinase-1
- RS10488 (MMP1) ??
- RS514921 (MMP1) ??
- RS5854 (MMP1) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
MMP1 Interacts with These Diseases
Disease | Score |
Substances That Increase MMP1
Substances | Interaction | Organism | Category |
Substances That Decrease MMP1
Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Recessive dystrophic epidermolysis bullosaChronic obstructive pulmonary disease
From NCBI Gene: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] From UniProt: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Can be activated without removal of the activation peptide.
Cofactor:
Binds 2 Zn(2+) ions per subunit.
Molecular Function:
- Calcium Ion Binding
- Endopeptidase Activity
- Metalloendopeptidase Activity
- Serine-Type Endopeptidase Activity
- Zinc Ion Binding
Biological Processes:
- Cellular Protein Metabolic Process
- Collagen Catabolic Process
- Extracellular Matrix Disassembly
- Leukocyte Migration
- Positive Regulation Of Protein Oligomerization
- Proteolysis
- Viral Process