This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium [R]

     From NCBI Gene: Membranous nephropathy, susceptibility to

     From NCBI Gene: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] From UniProt: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

The following transcription factors affect gene expression:

• NF-kappaB
• p53
• AP-1
• c-Jun
• NF-kappaB1
• Sp1

Enzyme Regulation:

Inhibited in a dose dependent manner by opiorphin.

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

• Endopeptidase Activity
• Metalloendopeptidase Activity
• Metallopeptidase Activity
• Exopeptidase Activity
• Zinc Ion Binding
• Peptide Binding

Biological Processes:

• Kidney Development
• Angiotensin Maturation
• Proteolysis
• Peptide Metabolic Process
• Sensory Perception Of Pain
• Creatinine Metabolic Process
• Beta-Amyloid Metabolic Process
• Cellular Response To Cytokine Stimulus
• Cellular Response To Uv-A
• Cellular Response To Uv-B
• Replicative Senescence

Drug Bank:

• Sacubitril
• Liraglutide
• Candoxatril