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  3. MME

MME (Membrane metalloendopeptidase)

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Summary of MME

This gene encodes for an antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia [R]

 

 

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The Function of MME

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

Protein names

Recommended name:

Neprilysin

Short name:

NEP

Alternative name(s):

Atriopeptidase
Common acute lymphocytic leukemia antigen
CALLA
Enkephalinase
Neutral endopeptidase 24.11
Neutral endopeptidase
Skin fibroblast elastase
SFE
CD antigen CD10

MME SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS989692 (MME) ??

Top Gene-Substance Interactions

MME Interacts with These Diseases

Disease Score

Substances That Increase MME

Substances Interaction Organism Category

Substances That Decrease MME

Substances Interaction Organism Category

Advanced Summary

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium [R]

     From NCBI Gene: Membranous nephropathy, susceptibility to

     From NCBI Gene: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] From UniProt: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • Sp1

Gene Pathways:

  • Metabolism of proteins
  • Alzheimer's disease
  • Hematopoietic cell lineage
  • Protein digestion and absorption
  • Renin-angiotensin system

Enzyme Regulation:

Inhibited in a dose dependent manner by opiorphin.

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Endopeptidase Activity
  • Exopeptidase Activity
  • Metalloendopeptidase Activity
  • Metallopeptidase Activity
  • Peptide Binding
  • Zinc Ion Binding

Biological Processes:

  • Angiotensin Maturation
  • Beta-Amyloid Metabolic Process
  • Cellular Response To Cytokine Stimulus
  • Cellular Response To Uv-A
  • Cellular Response To Uv-B
  • Creatinine Metabolic Process
  • Kidney Development
  • Peptide Metabolic Process
  • Proteolysis
  • Replicative Senescence
  • Sensory Perception Of Pain

Drug Bank:

  • Sacubitril
  • Liraglutide
  • Candoxatril
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| NEP| CMT2T| neprilysin| Anapl_03048| AS27_08424| AS28_05784| Atriopeptidase| C85356| CALLA| CB1_001103019| CD10| common acute lymphoblastic leukemia antigen| common acute lymphocytic leukemia antigen| D623_10024452| EGK_11980| EH28_15240| endopeptidase-related protein| enkephalinase| GW7_02962| H920_10670| I79_004237| M959_14283| membrane metallo endopeptidase| membrane metallo-endopeptidase| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)| membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase)| membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)| membrane metallo-endopeptidase variant 1| membrane metallo-endopeptidase variant 2| N300_11859| N301_00518| N302_12486| N303_11002| N305_10101| N306_10236| N307_08025| N308_07902| N309_07068| N310_02259| N312_13348| N320_09563| N321_10766| N322_13797| N324_10082| N325_12270| N326_12987| N327_00740| N330_12514| N331_12439| N332_00525| N333_09173| N334_04751| N335_08798| N336_08706| N339_03645| N340_02405| N341_11497| neprilysin-390| neprilysin-410 short isoform| neprilysin-411| neprilysin-like protein| neutral endopeptidase| neutral endopeptidase 24.11| PAL_GLEAN10018476| PANDA_021116| SCA43| SFE| skin fibroblast elastase| TREES_T100009850| UY3_04730| Y1Q_028262| Z169_03311| mme

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