The Function of MLYCD
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.
Protein names
Recommended name:
Malonyl-CoA decarboxylase, mitochondrialShort name:
MCDTop Gene-Substance Interactions
Substances That Increase MLYCD
| Substances | Interaction | Organism | Category |
Substances That Decrease MLYCD
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine.
Gene Pathways:
Enzyme Regulation:
Malonyl-CoA decarboxylase activity does not require any cofactors or divalent metal ions. Formation of interchain disulfide bonds leads to positive cooperativity between active sites and increases the affinity for malonyl-CoA and the catalytic efficiency (in vitro).
Molecular Function:
Biological Processes:
- Acetyl-Coa Biosynthetic Process
- Acyl-Coa Metabolic Process
- Fatty Acid Biosynthetic Process
- Malonyl-Coa Catabolic Process
- Positive Regulation Of Fatty Acid Oxidation
- Regulation Of Glucose Metabolic Process
- Response To Ischemia