The Function of MIP
Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).
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Protein names
Recommended name:
Lens fiber major intrinsic proteinShort name:
MP26Alternative name(s):
Aquaporin-0MIP26
Top Gene-Substance Interactions
Substances That Increase MIP
| Substances | Interaction | Organism | Category |
Substances That Decrease MIP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Major component of lens fiber gap junctions.
Gene Pathways:
Molecular Function:
- Structural Constituent Of Eye Lens
- Transporter Activity
- Gap Junction Channel Activity
- Calmodulin Binding
- Water Channel Activity
- Glycerol Channel Activity
Biological Processes:
- Lens Development In Camera-Type Eye
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Water Transport
- Visual Perception
- Cellular Water Homeostasis
- Canalicular Bile Acid Transport
- Ion Transmembrane Transport
- Positive Regulation Of Cell Adhesion
- Response To Stimulus
- Protein Homotetramerization
- Gap Junction-Mediated Intercellular Transport