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  3. MIP

MIP (Major intrinsic protein of lens fiber)

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The Function of MIP

Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).

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Protein names

Recommended name:

Lens fiber major intrinsic protein

Short name:

MP26

Alternative name(s):

Aquaporin-0
MIP26

Top Gene-Substance Interactions

Substances That Increase MIP

Substances Interaction Organism Category

Substances That Decrease MIP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • Max
  • NF-kappaB1
  • Sp1
  • c-Myb

Tissue specificity:

Major component of lens fiber gap junctions.

Gene Pathways:

  • Transmembrane transport of small molecules

Molecular Function:

  • Calmodulin Binding
  • Gap Junction Channel Activity
  • Glycerol Channel Activity
  • Structural Constituent Of Eye Lens
  • Transporter Activity
  • Water Channel Activity

Biological Processes:

  • Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
  • Cellular Water Homeostasis
  • Gap Junction-Mediated Intercellular Transport
  • Ion Transmembrane Transport
  • Lens Development In Camera-Type Eye
  • Positive Regulation Of Cell Adhesion
  • Protein Homotetramerization
  • Response To Stimulus
  • Visual Perception
  • Water Transport
  • Canalicular Bile Acid Transport
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| aquaporin| ASB| major intrinsic protein of eye lens fiber| MIP-3| Cat| MIP-2| AGAP000833-PA| AGAP000833-PB| allatostatin B| allatostatin-B| allatostatin B-1| allatostatin-B1| allatostatin (B-type)| allatostatin cricket-type| allatostatins MIP| allostatin B| AQP0| aquaporin 0| Aquaporin-0| AstB| AST-B| AstB-1| cataract and small eye| CB1_000449035| CG6456 gene product from transcript CG6456-RA| CG6456-PA| CTRCT15| Cts| DAP-B| Dmel_CG6456| DmMIP1| DmMIP2| DmMIP3| DmMIP4| DmMIP5| dominant cataract| Drm-MIP| Drm-MIP-1| Drm-MIP-2| Drm-MIP-3| Drm-MIP-4| Drm-MIP-5| Drostatin-B1| drostatin-B2| Drostatin-B3| Drostatin-B4| Drostatin-B5| EH28_17131| ENSANGG00000007733| GW7_15751| H920_14050| Hfi| hydropic fibers| Lens fiber major intrinsic protein| lens opacity| lim1| Lop| M91_19743| major intrinsic protein of eye lens fiber-like protein| mioinhibiting peptide precursor| MIP-1| MIP26| MIP-4| MIP-5| Mip-like peptide| Mip-PA| MP22| MP26| myoinhibiting peptide| myoinhibiting peptide precursor| myoinhibitory peptide| PAL_GLEAN10004828| PANDA_004093| shrivelled| Svl| TREES_T100006911| Y1Q_007564| mip

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