The Function of MIP
Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).
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Protein names
Recommended name:
Lens fiber major intrinsic proteinShort name:
MP26Alternative name(s):
Aquaporin-0MIP26
Top Gene-Substance Interactions
Substances That Increase MIP
| Substances | Interaction | Organism | Category |
Substances That Decrease MIP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Major component of lens fiber gap junctions.
Gene Pathways:
Molecular Function:
- Calmodulin Binding
- Gap Junction Channel Activity
- Glycerol Channel Activity
- Structural Constituent Of Eye Lens
- Transporter Activity
- Water Channel Activity
Biological Processes:
- Regulation Of Transcription, Dna-Templated
- Transcription, Dna-Templated
- Cellular Water Homeostasis
- Gap Junction-Mediated Intercellular Transport
- Ion Transmembrane Transport
- Lens Development In Camera-Type Eye
- Positive Regulation Of Cell Adhesion
- Protein Homotetramerization
- Response To Stimulus
- Visual Perception
- Water Transport
- Canalicular Bile Acid Transport