The Function of MIF
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
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Protein names
Recommended name:
Macrophage migration inhibitory factorShort name:
MIFAlternative name(s):
Glycosylation-inhibiting factorGIF
L-dopachrome isomerase
L-dopachrome tautomerase
Phenylpyruvate tautomerase
Top Gene-Substance Interactions
MIF Interacts with These Diseases
| Disease | Score |
Substances That Increase MIF
| Substances | Interaction | Organism | Category |
Substances That Decrease MIF
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.
Molecular Function:
- Dopachrome Isomerase Activity
- Receptor Binding
- Cytokine Activity
- Cytokine Receptor Binding
- Chemoattractant Activity
- Phenylpyruvate Tautomerase Activity
Biological Processes:
- Prostaglandin Biosynthetic Process
- Negative Regulation Of Mature B Cell Apoptotic Process
- Inflammatory Response
- Cell Surface Receptor Signaling Pathway
- Cell Aging
- Cell Proliferation
- Negative Regulation Of Gene Expression
- Positive Regulation Of Protein Kinase A Signaling
- Carboxylic Acid Metabolic Process
- Dna Damage Response, Signal Transduction By P53 Class Mediator
- Positive Regulation Of B Cell Proliferation
- Positive Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
- Negative Regulation Of Cellular Protein Metabolic Process
- Negative Regulation Of Myeloid Cell Apoptotic Process
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Phosphorylation
- Regulation Of Macrophage Activation
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Map Kinase Activity
- Negative Regulation Of Dna Damage Response, Signal Transduction By P53 Class Mediator
- Innate Immune Response
- Positive Regulation Of Fibroblast Proliferation
- Positive Regulation Of Cytokine Secretion
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Leukocyte Migration
- Positive Regulation Of Prostaglandin Secretion Involved In Immune Response
- Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response
- Protein Homotrimerization
- Positive Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Cell Cycle Arrest
- Positive Regulation Of Arachidonic Acid Secretion
- Negative Regulation Of Cell Aging
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage By P53 Class Mediator
- Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production