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  3. MIF

MIF (Macrophage migration inhibitory factor (glycosylation-inhibiting factor))

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The Function of MIF

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

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Protein names

Recommended name:

Macrophage migration inhibitory factor

Short name:

MIF

Alternative name(s):

Glycosylation-inhibiting factor
GIF
L-dopachrome isomerase
L-dopachrome tautomerase
Phenylpyruvate tautomerase

Top Gene-Substance Interactions

MIF Interacts with These Diseases

Disease Score

Substances That Increase MIF

Substances Interaction Organism Category

Substances That Decrease MIF

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • CREB
  • AhR
  • deltaCREB
  • NF-kappaB1
  • C/EBPbeta
  • Sp1

Gene Pathways:

  • Tyrosine metabolism
  • Phenylalanine metabolism

Induction:

Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.

Molecular Function:

  • Chemoattractant Activity
  • Cytokine Activity
  • Cytokine Receptor Binding
  • Dopachrome Isomerase Activity
  • Phenylpyruvate Tautomerase Activity
  • Receptor Binding

Biological Processes:

  • Carboxylic Acid Metabolic Process
  • Cell Aging
  • Cell Proliferation
  • Cell Surface Receptor Signaling Pathway
  • Dna Damage Response, Signal Transduction By P53 Class Mediator
  • Inflammatory Response
  • Innate Immune Response
  • Leukocyte Migration
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cell Aging
  • Negative Regulation Of Cell Cycle Arrest
  • Negative Regulation Of Cellular Protein Metabolic Process
  • Negative Regulation Of Dna Damage Response, Signal Transduction By P53 Class Mediator
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage By P53 Class Mediator
  • Negative Regulation Of Mature B Cell Apoptotic Process
  • Negative Regulation Of Myeloid Cell Apoptotic Process
  • Positive Regulation Of Arachidonic Acid Secretion
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
  • Positive Regulation Of Cytokine Secretion
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Fibroblast Proliferation
  • Positive Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
  • Positive Regulation Of Map Kinase Activity
  • Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response
  • Positive Regulation Of Peptidyl-Serine Phosphorylation
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Positive Regulation Of Phosphorylation
  • Positive Regulation Of Prostaglandin Secretion Involved In Immune Response
  • Positive Regulation Of Protein Kinase A Signaling
  • Prostaglandin Biosynthetic Process
  • Protein Homotrimerization
  • Regulation Of Macrophage Activation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| mif| gif| AS28_08495| CB1_000302032| delayed early response protein 6| DER6| Glif| glutathione-binding 13 kDa protein| glycosylation-inhibiting factor| GW7_18919| L-dopachrome isomerase| L-dopachrome tautomerase| macrophage migration inhibitory factor| macrophage migration inhibitory factor-like protein| mmif| N300_08142| N302_15514| N306_04892| N307_12358| N310_00163| N312_00383| N320_09418| N324_10689| N325_09828| N326_05972| N327_00255| N328_00186| N331_11071| N332_07145| N333_04493| N334_00478| N335_00301| N336_00207| N340_11993| N341_03545| p12A| PAL_GLEAN10010866| PANDA_014531| phenylpyruvate tautomerase| TREES_T100012824| Y956_15728| Z169_10721

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