Summary of MGP
The gene codes for a protein, matrix Gla protein. Defects may lead to Keutel syndrome (KS) [R].
The Function of MGP
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Protein names
Recommended name:
Matrix Gla proteinShort name:
MGPAlternative name(s):
Cell growth-inhibiting gene 36 protein- RS1800801 (MGP) ??
- RS1800802 (MGP) ??
- RS4236 (MGP) ??
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Top Gene-Substance Interactions
MGP Interacts with These Diseases
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Substances That Increase MGP
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Substances That Decrease MGP
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Advanced Summary
From NCBI Gene: Keutel syndromeFrom UniProt: Keutel syndrome (KTLS): An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. [MIM:245150]
From NCBI Gene: The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] From UniProt: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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