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MGP (Matrix Gla protein)

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Summary of MGP

The gene codes for a protein, matrix Gla protein. Defects may lead to Keutel syndrome (KS) [R].

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The Function of MGP

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Protein names

Recommended name:

Matrix Gla protein

Short name:

MGP

Alternative name(s):

Cell growth-inhibiting gene 36 protein

MGP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1800801 (MGP) ??
  2. RS1800802 (MGP) ??
  3. RS4236 (MGP) ??

Top Gene-Substance Interactions

MGP Interacts with These Diseases

Disease Score

Substances That Increase MGP

Substances Interaction Organism Category

Substances That Decrease MGP

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Keutel syndromeFrom UniProt: Keutel syndrome (KTLS): An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. [MIM:245150]

     From NCBI Gene: The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] From UniProt: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • Sox9
  • p300

Molecular Function:

  • Calcium Ion Binding
  • Extracellular Matrix Structural Constituent
  • Structural Constituent Of Bone

Biological Processes:

  • Cartilage Condensation
  • Cell Differentiation
  • Ossification
  • Regulation Of Bone Mineralization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_07995| AS28_12585| CB1_001683022| cell growth-inhibiting gene 36 protein| EGK_03423| GIG36| GW7_19632| H920_11389| I79_005250| M91_04351| M959_13570| matrix gamma-carboxyglutamate (gla) protein| Mglap| MPG| N300_13107| N301_15974| N302_12829| N303_14860| N305_08126| N306_04275| N307_06714| N308_05185| N309_01415| N310_07346| N311_09384| N321_03792| N322_04333| N324_10292| N325_09170| N326_03773| N327_10590| N328_09162| N330_12437| N332_11917| N333_10628| N334_11664| N335_03454| N336_06631| N339_10176| N340_10405| N341_00784| NTI| PAL_GLEAN10015642| PANDA_018362| TREES_T100003662| xmgp| Y1Q_030530| Y956_04100| mgp

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