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  3. MGMT

MGMT (O-6-methylguanine-DNA methyltransferase)

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Summary of MGMT

The gene encodes a protein that is a DNA repair protein that is involved in cellular defense against alkylating agents. Alkylating agents are carcinogens that can result in cell death, mutation and cancer. Mutations of the gene is associated with several cancer types (R). 

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The Function of MGMT

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Protein names

Recommended name:

Methylated-DNA--protein-cysteine methyltransferase

Short name:

MGMT

Alternative name(s):

6-O-methylguanine-DNA methyltransferase
O-6-methylguanine-DNA-alkyltransferase

MGMT SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11016883 (MGMT) ??
  2. RS12917 (MGMT) ??
  3. RS16906252 (MGMT) ??
  4. RS1803965 (MGMT) ??
  5. RS2308321 (MGMT) ??
  6. RS2308327 (MGMT) ??
  7. RS2388328 (MGMT) ??
  8. RS477692 (MGMT) ??
  9. RS80312298 (MGMT) ??

Top Gene-Substance Interactions

MGMT Interacts with These Diseases

Disease Score

Substances That Increase MGMT

Substances Interaction Organism Category

Substances That Decrease MGMT

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • NF-kappaB1
  • Sp1
  • IRF-1
  • IRF-2

Gene Pathways:

  • DNA Repair

Cofactor:

Binds 1 zinc ion.

Molecular Function:

  • Calcium Ion Binding
  • Damaged Dna Binding
  • Dna Binding
  • Dna-Methyltransferase Activity
  • Methylated-Dna-
  • Methyltransferase Activity
  • Methylated-Dna-[Protein]-Cysteine S-Methyltransferase Activity

Biological Processes:

  • Cellular Response To Ionizing Radiation
  • Cellular Response To Organic Cyclic Compound
  • Cellular Response To Oxidative Stress
  • Dna Dealkylation Involved In Dna Repair
  • Dna Ligation
  • Mammary Gland Epithelial Cell Differentiation
  • Negative Regulation Of Apoptotic Process
  • Positive Regulation Of Double-Strand Break Repair
  • Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Response To Ethanol
  • Response To Folic Acid
  • Response To Toxic Substance

Drug Bank:

  • L-Cysteine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| O-6-alkylguanine-DNA alkyltransferase| 0-6-methylguanine-DNA methyltransferase| 6-O-methylguanine-DNA methyltransferase| Agat| AGT| AS27_02881| AS28_09666| CB1_000436005| D623_10024815| H920_00355| I79_020561| M91_12513| M959_08651| MDA_GLEAN10021277| methylated-DNA-protein-cysteine methyltransferase| Methylated-DNA--protein-cysteine methyltransferase| methylated-DNA--protein-cysteine methyltransferase-like protein| methylguanine-DNA methyltransferase| N300_07065| N302_12052| N303_05188| N305_01517| N307_11425| N310_12523| N321_01804| O(6)-alkylguanine-DNA alkyltransferase| O6-alkylguanine-DNA alkyltransferase| O6-alkylguanine-DNA-alkyltransferase| O-6-methylguanine-DNA-alkyltransferase| O6-methylguanine-DNA methyltranferase| O6-methylguanine-DNA methyltransferase| O6-methylguanine-DNA-methyltransferase| O6-MGMT| PANDA_011845| TREES_T100016901| Y1Q_002171| Y956_03013| Z169_02465| mgmt

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