Summary of MGMT
The gene encodes a protein that is a DNA repair protein that is involved in cellular defense against alkylating agents. Alkylating agents are carcinogens that can result in cell death, mutation and cancer. Mutations of the gene is associated with several cancer types (R).
The Function of MGMT
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Protein names
Recommended name:
Methylated-DNA--protein-cysteine methyltransferaseShort name:
MGMTAlternative name(s):
6-O-methylguanine-DNA methyltransferaseO-6-methylguanine-DNA-alkyltransferase
- RS11016883 (MGMT) ??
- RS12917 (MGMT) ??
- RS16906252 (MGMT) ??
- RS1803965 (MGMT) ??
- RS2308321 (MGMT) ??
- RS2308327 (MGMT) ??
- RS2388328 (MGMT) ??
- RS477692 (MGMT) ??
- RS80312298 (MGMT) ??
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Top Gene-Substance Interactions
MGMT Interacts with These Diseases
| Disease | Score |
Substances That Increase MGMT
| Substances | Interaction | Organism | Category |
Substances That Decrease MGMT
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 1 zinc ion.
Molecular Function:
- Dna Binding
- Damaged Dna Binding
- Methylated-Dna-[Protein]-Cysteine S-Methyltransferase Activity
- Calcium Ion Binding
- Methyltransferase Activity
- Dna-Methyltransferase Activity
- Methylated-Dna-
Biological Processes:
- Dna Ligation
- Dna Dealkylation Involved In Dna Repair
- Response To Toxic Substance
- Cellular Response To Oxidative Stress
- Negative Regulation Of Apoptotic Process
- Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Response To Ethanol
- Response To Folic Acid
- Mammary Gland Epithelial Cell Differentiation
- Cellular Response To Organic Cyclic Compound
- Cellular Response To Ionizing Radiation
- Positive Regulation Of Double-Strand Break Repair
Drug Bank:
- L-Cysteine