• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. MET

MET (MET proto-oncogene, receptor tyrosine kinase)

Loading...

Summary of MET

This gene encodes a protein that plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations of this gene are associated with different types of cancer (R). 

0 users want this gene increased, 0 users want it decreased

The Function of MET

Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

Protein names

Recommended name:

SAFB-like transcription modulator

Alternative name(s):

Modulator of estrogen-induced transcription

MET SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10243024 (MET) ??
  2. RS1621 (MET) ??
  3. RS1858830 (MET) ??
  4. RS2237717 (MET) ??
  5. RS2402118 (MET) ??
  6. RS38845 (MET) ??
  7. RS38855 (MET) ??
  8. RS38857 (MET) ??
  9. RS41741 (MET) ??

Top Gene-Substance Interactions

MET Interacts with These Diseases

Disease Score

Substances That Increase MET

Substances Interaction Organism Category

Substances That Decrease MET

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: nonsyndromic hearing lossFrom NCBI Gene: Hepatocellular carcinomaRenal cell carcinoma, papillary, 1Osteofibrous dysplasiaDeafness, autosomal recessive 97From UniProt: A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes. Renal cell carcinoma papillary (RCCP): A subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. [MIM:605074] Defects in MET may be associated with gastric cancer. Hepatocellular carcinoma (HCC): A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. [MIM:114550] MET activating mutations may be involved in the development of a highly malignant, metastatic syndrome known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread is generally a late event in cancer progression. However, in some instances, distant dissemination arises at a very early stage, so that metastases reach clinical relevance before primary lesions. Sometimes, the primary lesions cannot be identified in spite of the progresses in the diagnosis of malignancies. Deafness, autosomal recessive, 97 (DFNB97): A form of non-syndromic sensorineural hearing loss with prelingual onset. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. [MIM:616705] Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.

     From NCBI Gene: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] From UniProt: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • p53
  • Sp1
  • NF-1
  • Bach2
  • p300

Tissue specificity:

Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977).

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Pathways in cancer
  • Epithelial cell signaling in Helicobacter pylori infection
  • Axon guidance
  • Melanoma
  • Malaria
  • Bacterial invasion of epithelial cells
  • Adherens junction
  • Renal cell carcinoma

Enzyme Regulation:

In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.

Molecular Function:

  • Atp Binding
  • Hepatocyte Growth Factor-Activated Receptor Activity
  • Protein Phosphatase Binding
  • Protein Tyrosine Kinase Activity
  • Double-Stranded Dna Binding
  • Nucleotide Binding
  • Poly(A) Rna Binding
  • Sequence-Specific Dna Binding

Biological Processes:

  • Branching Morphogenesis Of An Epithelial Tube
  • Cell Proliferation
  • Cell Surface Receptor Signaling Pathway
  • Endothelial Cell Morphogenesis
  • Negative Regulation Of Autophagy
  • Negative Regulation Of Hydrogen Peroxide-Mediated Programmed Cell Death
  • Positive Chemotaxis
  • Positive Regulation Of Endothelial Cell Chemotaxis
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Semaphorin-Plexin Signaling Pathway
  • Signal Transduction
  • Apoptotic Process
  • Regulation Of Mrna Processing
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated

Drug Bank:

  • Crizotinib
  • Cabozantinib
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| tyrosine kinase| HGF| AS27_03512| AS28_05696| AUTS9| bHLHe59| CB1_000316005| CG1705 gene product from transcript CG1705-RB| CG1705-PA| CG1705-PB| cmet| c-Met| D623_10018982| DFNB97| Dmel_CG1705| DmMet| EGK_14061| growth factor receptor c-met| H920_04322| Hepatocyte growth factor receptor| hepatocyte growth factor receptor-like protein| Hgfr| HGF receptor| HGF receptor c-Met| HGF/SF receptor| I79_007063| juvenile hormone resistance| M91_16200| M959_12840| macrophage stimulating 1 receptor (c-met-related tyrosine kinase)| MDA_GLEAN10003316| methoprene tolerant| Methoprene-tolerant| Methoprene-tolerant protein| Met/Met1| Met-PA| Met-PB| met proto-oncogene| met proto-oncogene (hepatocyte growth factor receptor)| met proto-oncogene tyrosine kinase| met proto-oncoprotein| Mett| MST1R| N301_16372| N303_08951| N306_00647| N307_04073| N308_04918| N309_11121| N310_11515| N311_00724| N312_13765| N321_03402| N322_00507| N324_02555| N326_04052| N327_08710| N328_11582| N329_03899| N330_02675| N331_08779| N332_10590| N333_13326| N334_05625| N335_02210| N336_12651| N339_09042| N340_00938| N341_12072| PAL_GLEAN10019217| PANDA_005689| Par4| proto-oncogene c-Met| proto-oncogene, receptor tyrosine kinase| RCCP2| resistance (1) juvenile H| resistance to juvenile hormone| Rst(1)JH| scatter factor receptor| SF receptor| TREES_T100021969| Tyrosine-protein kinase Met| Y1Q_003488| Z169_03161| met

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved