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MERTK (MER proto-oncogene, tyrosine kinase)

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Summary of MERTK

The gene codes for a protein, MER proto-oncogene, tyrosine kinase. Mutations may cause disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) [R].

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The Function of MERTK

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Protein names

Recommended name:

Tyrosine-protein kinase Mer

Alternative name(s):

Proto-oncogene c-Mer
Receptor tyrosine kinase MerTK

MERTK SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17174870 (MERTK) ??
  2. RS4374383 (MERTK) ??
  3. RS7604639 (MERTK) ??

Top Gene-Substance Interactions

MERTK Interacts with These Diseases

Disease Score

Substances That Increase MERTK

Substances Interaction Organism Category

Substances That Decrease MERTK

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: retinitis pigmentosaFrom NCBI Gene: Retinitis pigmentosa 38From UniProt: Retinitis pigmentosa 38 (RP38): A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. [MIM:613862]

     From NCBI Gene: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] From UniProt: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

Gene Pathways:

  • Hemostasis

Molecular Function:

  • Atp Binding
  • Transmembrane Receptor Protein Tyrosine Kinase Activity

Biological Processes:

  • Apoptotic Cell Clearance
  • Cell-Cell Signaling
  • Cell Surface Receptor Signaling Pathway
  • Leukocyte Migration
  • Natural Killer Cell Differentiation
  • Negative Regulation Of Leukocyte Apoptotic Process
  • Negative Regulation Of Lymphocyte Activation
  • Phagocytosis
  • Platelet Activation
  • Positive Regulation Of Phagocytosis
  • Protein Kinase B Signaling
  • Protein Phosphorylation
  • Retina Development In Camera-Type Eye
  • Secretion By Cell
  • Spermatogenesis
  • Substrate Adhesion-Dependent Cell Spreading
  • Vagina Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Tyrosine-protein kinase Mer| A306_12353| AS27_04164| AS28_01724| CB1_000688018| c-Eyk| c-eyk proto-oncogene| c-mer| c-mer proto-oncogene tyrosine kinase| D623_10004719| Eyk| GW7_17937| H920_11264| I79_003454| M91_11443| M959_03782| MDA_GLEAN10004141| MER| MER receptor tyrosine kinase| N300_10179| N301_10941| N303_00725| N305_05061| N306_15585| N307_02246| N308_08490| N320_09423| N322_07888| N330_11386| N332_10083| N335_11966| N339_05262| nmf12| Nyk| PAL_GLEAN10005638| PANDA_013676| proto-oncogene c-Mer| Proto-oncogene tyrosine-protein kinase MER| rdy| receptor tyrosine kinase MerTK| Receptor tyrosine tinase gene probably the gene for Rdy| retinal dystrophy| RP38| STK kinase| TREES_T100021672| Tyro12| Tyro 12| TYRO3| TYRO3 protein tyrosine kinase| UY3_06250| Y1Q_013912| Y956_14488| mertk

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