The Function of MEOX2
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
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Protein names
Recommended name:
Homeobox protein MOX-2Alternative name(s):
Growth arrest-specific homeoboxMesenchyme homeobox 2
Top Gene-Substance Interactions
Substances That Increase MEOX2
| Substances | Interaction | Organism | Category |
Substances That Decrease MEOX2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Embryo and placenta.
Molecular Function:
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
Biological Processes:
- Angiogenesis
- Blood Circulation
- Limb Development
- Multicellular Organism Development
- Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
- Neuron Death
- Palate Development
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Skeletal Muscle Tissue Development
- Somite Specification