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  3. MEOX2

MEOX2 (Mesenchyme homeobox 2)

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The Function of MEOX2

Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

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Protein names

Recommended name:

Homeobox protein MOX-2

Alternative name(s):

Growth arrest-specific homeobox
Mesenchyme homeobox 2

Top Gene-Substance Interactions

Substances That Increase MEOX2

Substances Interaction Organism Category

Substances That Decrease MEOX2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • FOXO4
  • NF-kappaB1
  • TBP
  • TFIID

Tissue specificity:

Embryo and placenta.

Molecular Function:

  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Angiogenesis
  • Blood Circulation
  • Limb Development
  • Multicellular Organism Development
  • Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
  • Neuron Death
  • Palate Development
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Skeletal Muscle Tissue Development
  • Somite Specification
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| MOX2| Anapl_02788| AS28_02812| CB1_000620003| EGK_13891| gax| growth arrest homeobox transcription factor GAX| growth arrest-specific homeobox| H920_13496| homeobox protein Hox-C4a| Homeobox protein MOX-2| homeobox protein MOX-2-like protein| M959_01714| meox2-a| meox2-b| mesenchyme homeo box 2 (growth arrest-specific homeo box)| mox-2| N300_01016| N301_12620| N302_03124| N303_06279| N306_04482| N307_00384| N308_15986| N309_12752| N312_06969| N321_09645| N322_09163| N332_02964| PAL_GLEAN10021790| PANDA_005667| UY3_16292| Y1Q_022757| Y956_03076| Z169_04371| meox2

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