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  3. MEIS1

MEIS1 (Meis homeobox 1)

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Summary of MEIS1

The gene codes for a protein, Meis homeobox 1. It codes a homeobox protein as part of the TALE ('three amino acid loop extension') family of homeodomain-containing proteins [R].

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The Function of MEIS1

Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Protein names

Recommended name:

Homeobox protein Meis1

MEIS1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10865355 (MEIS1) ??
  2. RS11678354 (MEIS1) ??
  3. RS11897119 (MEIS1) ??
  4. RS12469063 (MEIS1) ??
  5. RS2300478 (MEIS1) ??
  6. RS3891585 (MEIS1) ??
  7. RS6710341 (MEIS1) ??

Top Gene-Substance Interactions

Substances That Increase MEIS1

Substances Interaction Organism Category

Substances That Decrease MEIS1

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: restless legs syndromeFrom UniProt: Restless legs syndrome 7 (RLS7): A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. [MIM:612853]

     From NCBI Gene: Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008] From UniProt: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • C/EBPalpha
  • Zic1
  • Meis-1
  • Pax-2
  • Meis-1b

Tissue specificity:

Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.

Molecular Function:

  • Chromatin Binding
  • Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding

Biological Processes:

  • Angiogenesis
  • Definitive Hemopoiesis
  • Lens Morphogenesis In Camera-Type Eye
  • Locomotory Behavior
  • Megakaryocyte Development
  • Negative Regulation Of Myeloid Cell Differentiation
  • Negative Regulation Of Neuron Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04152| AS27_09380| AS28_11144| CB1_056349001| D623_10034265| Evi8| GW7_10408| H920_17497| Homeobox protein Meis1| Homeobox protein Meis2| leukemogenic homolog protein| M91_09141| M959_10792| meis| Meis1, myeloid ecotropic viral integration site 1 homolog| MEIS2| Meis homeobox 2| myeloid ecotropic viral insertion site-1a2 protein| myeloid ecotropic viral insertion site-1a protein| myeloid ecotropic viral integration site 1| N300_08756| N301_00718| N302_10452| N303_01245| N305_03653| N306_13255| N307_07859| N308_08540| N310_09894| N312_00184| N324_00812| N326_06730| N333_09378| PAL_GLEAN10021191| PANDA_006146| TREES_T100017484| UY3_09923| WUGSC:H_NH0444B04.1| XMeis1| Y1Q_030232| Y956_07394| meis1

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