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  3. ME1

ME1 (Malic enzyme 1)

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Protein names

Recommended name:

NADP-dependent malic enzyme

Short name:

NADP-ME

Alternative name(s):

Malic enzyme 1

ME1 SNPs

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  1. RS12195417 (ME1) ??

Top Gene-Substance Interactions

ME1 Interacts with These Diseases

Disease Score

Substances That Increase ME1

Substances Interaction Organism Category

Substances That Decrease ME1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Expressed in all tissues tested including liver, placenta and white adipose tissue.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • PPAR signaling pathway
  • Pyruvate metabolism

Cofactor:

Divalent metal cations. Prefers magnesium or manganese.

Molecular Function:

  • Adp Binding
  • Electron Carrier Activity
  • Malate Dehydrogenase (Decarboxylating) (Nad+) Activity
  • Malate Dehydrogenase (Decarboxylating) (Nadp+) Activity
  • Malic Enzyme Activity
  • Manganese Ion Binding
  • Nad Binding
  • Nadp Binding
  • Oxaloacetate Decarboxylase Activity

Biological Processes:

  • Carbohydrate Metabolic Process
  • Malate Metabolic Process
  • Nadp Biosynthetic Process
  • Protein Tetramerization
  • Regulation Of Nadp Metabolic Process
  • Response To Carbohydrate
  • Response To Hormone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00577| AS27_06445| AS28_12084| CB1_000212009| cytosolic malic enzyme 1| D623_10024951| D9Ertd267e| EGK_15118| H920_08229| HUMNDME| I79_000906| M91_01898| M959_03736| malate dehydrogenase| malate dehydrogenase decarboxylase (NADP+)| malate dehydrogenase (NADP+)| malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))| malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)| malic enzyme 1, NADP(+)-dependent, cytoplasmic (cytosolic, soluble)| malic enzyme 1, NADP-dependent, cytosolic| malic enzyme 1, NADP(+)-dependent, cytosolic| malic enzyme 1, soluble| Malic enzyme, cytoplasmic| malic enzyme, supernatant| Mdh-1| MES| Mod1| Mod-1| N300_01123| N301_04191| N302_15553| N303_02336| N305_14243| N306_02175| N307_03048| N308_11564| N309_01039| N311_08265| N312_10045| N321_00546| N322_05548| N324_11896| N325_08128| N332_04802| N335_06156| N339_03300| N341_12798| NADP-dependent malic enzyme| NADP-dependent malic enzyme-like protein| NADP-ME| PAL_GLEAN10025209| PANDA_014734| pyruvic-malic carboxylase| TREES_T100001442| UY3_06182| Y1Q_028086| Y956_07873| Z169_10502| me1

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