The Function of MDM4
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
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Protein names
Recommended name:
Protein Mdm4Alternative name(s):
Double minute 4 proteinMdm2-like p53-binding protein
Protein Mdmx
p53-binding protein Mdm4
- RS12143943 (MDM4) ??
- RS2290854 (MDM4) ??
- RS4245739 (MDM4) ??
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Top Gene-Substance Interactions
Substances That Increase MDM4
| Substances | Interaction | Organism | Category |
Substances That Decrease MDM4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues tested with high levels in thymus.
Gene Pathways:
Induction:
Down-regulated by cisplatin (at protein level).
Molecular Function:
Biological Processes:
- Cell Proliferation
- Cellular Response To Hypoxia
- Dna Damage Response, Signal Transduction By P53 Class Mediator
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
- G0 To G1 Transition
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Cell Cycle Arrest
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Protein Catabolic Process
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Protein Complex Assembly
- Protein Stabilization
- Regulation Of Signal Transduction By P53 Class Mediator