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  3. MDM4

MDM4 (MDM4, p53 regulator)

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The Function of MDM4

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

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Protein names

Recommended name:

Protein Mdm4

Alternative name(s):

Double minute 4 protein
Mdm2-like p53-binding protein
Protein Mdmx
p53-binding protein Mdm4

MDM4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12143943 (MDM4) ??
  2. RS2290854 (MDM4) ??
  3. RS4245739 (MDM4) ??

Top Gene-Substance Interactions

Substances That Increase MDM4

Substances Interaction Organism Category

Substances That Decrease MDM4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • p300

Tissue specificity:

Expressed in all tissues tested with high levels in thymus.

Gene Pathways:

  • p53 signaling pathway

Induction:

Down-regulated by cisplatin (at protein level).

Molecular Function:

  • Enzyme Binding
  • Ubiquitin Protein Ligase Activity
  • Zinc Ion Binding

Biological Processes:

  • Cell Proliferation
  • Cellular Response To Hypoxia
  • Dna Damage Response, Signal Transduction By P53 Class Mediator
  • Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
  • G0 To G1 Transition
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cell Cycle Arrest
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Protein Catabolic Process
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Protein Complex Assembly
  • Protein Stabilization
  • Regulation Of Signal Transduction By P53 Class Mediator
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| mrp1| HDMX| A306_10121| AL023055| AS27_02013| AS28_04598| C85810| CB1_000597051| D623_10018510| double minute 4 homolog| double minute 4, human homolog of; p53-binding protein| double minute 4 protein| EGK_01759| GW7_11218| H920_18916| I79_007576| M91_12897| M959_03133| MDA_GLEAN10007117| mdm2-like p53-binding protein| Mdm4 p53 binding protein homolog| Mdm4 p53 binding protein-like protein| MDM4 protein variant G| MDM4 protein variant Y| MDM4-related protein 1| Mdm4, transformed 3T3 cell double minute 4, p53 binding protein| Mdmx| N300_03725| N302_14776| N303_11422| N305_13629| N306_12247| N307_09742| N309_15634| N310_00845| N311_05503| N312_02738| N320_10268| N321_01223| N322_02084| N324_02558| N325_01267| N326_08689| N327_03881| N328_06407| N329_07874| N330_07221| N331_04090| N332_08408| N333_04815| N334_07697| N335_13906| N336_01798| N339_04698| N340_02813| N341_03774| p53-binding protein Mdm4| PAL_GLEAN10006963| PANDA_006669| protein Mdm4| protein Mdmx| transformed 3T3 cell double minute 4 homolog| transformed mouse 3T3 cell double minute 4| UY3_12041| Y1Q_003531| Y956_10819| Z169_00403| mdm4

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