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  3. MCL1

MCL1 (BCL2 family apoptosis regulator)

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The Function of MCL1

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

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Protein names

Recommended name:

Induced myeloid leukemia cell differentiation protein Mcl-1

Alternative name(s):

Bcl-2-like protein 3
Bcl2-L-3
Bcl-2-related protein EAT/mcl1
mcl1/EAT

Top Gene-Substance Interactions

MCL1 Interacts with These Diseases

Disease Score

Substances That Increase MCL1

Substances Interaction Organism Category

Substances That Decrease MCL1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • STAT3
  • NF-kappaB1
  • STAT5A
  • GATA-2

Induction:

Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.

Molecular Function:

  • Bh3 Domain Binding
  • Protein Channel Activity
  • Protein Heterodimerization Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Apoptotic Mitochondrial Changes
  • Cell Fate Determination
  • Cellular Homeostasis
  • Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
  • Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
  • Multicellular Organism Development
  • Negative Regulation Of Anoikis
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Autophagy
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
  • Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
  • Positive Regulation Of Oxidative Stress-Induced Neuron Intrinsic Apoptotic Signaling Pathway
  • Regulation Of Response To Dna Damage Stimulus
  • Response To Cytokine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00560| Anapl_16713| AS27_10015| AS28_04112| bcl2l3| bcl2-L-3| bcl-2-like protein 3| Bcl-2-related protein| bcl-2-related protein EAT/mcl1| CB1_000914022| D623_10031842| EAT| H920_20395| I79_004573| Induced myeloid leukemia cell differentiation protein Mcl-1| induced myeloid leukemia cell differentiation protein Mcl-1 homolog| Induced myeloid leukemia cell differentiation protein Mcl-1-like| Induced myeloid leukemia cell differentiation protein Mcl-1 like protein| Induced myeloid leukemia cell differentiation protein Mcl-1-like protein| leukocyte receptor cluster member 8 homolog| M959_06315| mcl-1| mcl1/EAT| MCL1-ES| mcl1l| mcl1s| myeloid cell leukemia 1| myeloid cell leukemia ES| myeloid cell leukemia protein 1| myeloid cell leukemia protein MCL-1| myeloid cell leukemia sequence 1| myeloid cell leukemia sequence 1 (BCL2-related)| N300_14636| N301_16340| N302_02146| N303_11529| N306_01451| N308_01430| N309_14198| N310_05580| N312_05448| N320_04714| N321_06031| N322_07291| N326_02303| N327_06650| N328_05341| N329_03008| N330_06124| N331_04165| N332_08968| N333_07323| N334_05355| N335_05294| N336_06496| N339_05826| N340_09542| N341_08351| PAL_GLEAN10017542| TM| TREES_T100021289| Y1Q_015199| Y956_15304| Z169_02046| mcl1

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