The Function of MCL1
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
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Protein names
Recommended name:
Induced myeloid leukemia cell differentiation protein Mcl-1Alternative name(s):
Bcl-2-like protein 3Bcl2-L-3
Bcl-2-related protein EAT/mcl1
mcl1/EAT
Top Gene-Substance Interactions
MCL1 Interacts with These Diseases
| Disease | Score |
Substances That Increase MCL1
| Substances | Interaction | Organism | Category |
Substances That Decrease MCL1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Induction:
Expression increases early during phorbol ester-induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell line ML-1. Rapidly up-regulated by CSF2 in ML-1 cells. Up-regulated by heat shock-induced differentiation. Expression increases early during retinoic acid-induced differentiation.
Molecular Function:
- Bh3 Domain Binding
- Protein Channel Activity
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
Biological Processes:
- Apoptotic Mitochondrial Changes
- Cell Fate Determination
- Cellular Homeostasis
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage
- Multicellular Organism Development
- Negative Regulation Of Anoikis
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Autophagy
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
- Positive Regulation Of Oxidative Stress-Induced Neuron Intrinsic Apoptotic Signaling Pathway
- Regulation Of Response To Dna Damage Stimulus
- Response To Cytokine