The Function of MBP
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Protein names
Recommended name:
Bone marrow proteoglycanShort name:
MBPAlternative name(s):
BMPGProteoglycan 2
EMBP
Pregnancy-associated major basic protein
- RS11663697 (MBP) ??
- RS1789110 (MBP) ??
- RS8084125 (MBP) ??
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Top Gene-Substance Interactions
MBP Interacts with These Diseases
| Disease | Score |
Substances That Increase MBP
| Substances | Interaction | Organism | Category |
Substances That Decrease MBP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Developmental stage:
Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.
Molecular Function:
Biological Processes:
- Axon Ensheathment
- Central Nervous System Development
- Chemical Synaptic Transmission
- Immune Response
- Membrane Organization
- Myelination
- Response To Toxic Substance
- Sensory Perception Of Sound
- Substantia Nigra Development
- Defense Response To Bacterium
- Defense Response To Nematode
- Negative Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-4 Production
- Regulation Of Cytokine Biosynthetic Process
- Aging
- Negative Regulation Of Axonogenesis
- Response To Fatty Acid
- Response To Mercury Ion
- Response To Progesterone
- Response To Tumor Necrosis Factor