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  3. MBP

MBP (Myelin basic protein)

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The Function of MBP

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

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Protein names

Recommended name:

Bone marrow proteoglycan

Short name:

MBP

Alternative name(s):

BMPG
Proteoglycan 2
EMBP
Pregnancy-associated major basic protein

MBP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11663697 (MBP) ??
  2. RS1789110 (MBP) ??
  3. RS8084125 (MBP) ??

Top Gene-Substance Interactions

MBP Interacts with These Diseases

Disease Score

Substances That Increase MBP

Substances Interaction Organism Category

Substances That Decrease MBP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • AhR
  • c-Jun
  • PPAR-alpha
  • C/EBPalpha
  • Sp1
  • c-Fos
  • GATA-1
  • GATA-2

Tissue specificity:

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

Developmental stage:

Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks and its relative proportion declines thereafter.

Molecular Function:

  • Structural Constituent Of Myelin Sheath
  • Carbohydrate Binding
  • Heparin Binding

Biological Processes:

  • Axon Ensheathment
  • Central Nervous System Development
  • Chemical Synaptic Transmission
  • Immune Response
  • Membrane Organization
  • Myelination
  • Response To Toxic Substance
  • Sensory Perception Of Sound
  • Substantia Nigra Development
  • Defense Response To Bacterium
  • Defense Response To Nematode
  • Negative Regulation Of Interleukin-10 Production
  • Positive Regulation Of Interleukin-4 Production
  • Regulation Of Cytokine Biosynthetic Process
  • Aging
  • Negative Regulation Of Axonogenesis
  • Response To Fatty Acid
  • Response To Mercury Ion
  • Response To Progesterone
  • Response To Tumor Necrosis Factor
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 20 kDa microtubule-stabilizing protein| A306_03779| Anapl_15159| AS27_15926| AS28_02233| C76307| CB1_000345038| D623_10034204| EGK_09789| GekBS065P| Golli-MBP| golli protein J37.1| golli protein TP8.1| golli protein TP8S.1| H920_15598| Hmbpr| I79_018662| jve| M91_20724| M959_07526| Mbps| MBP S| MDA_GLEAN10025333| microtubule-stabilizing protein| mld| myelin A1 protein| myelin basic protein Golli-mbp| myelin basic protein-like protein| myelin basic protein S| myelin deficient| myelin membrane encephalitogenic protein| Myelin P1 protein| N300_05247| N301_04512| N302_10375| N303_05013| N305_12386| N306_12917| N307_07938| N308_07546| N309_08190| N311_05005| N320_09415| N321_00485| N324_12257| N326_01148| N327_09544| N329_11633| N331_04591| N332_12519| N333_08040| N334_00745| N335_03342| N339_11671| N340_10861| PANDA_015379| putative myelin basic protein variant 2| R75289| shi| shiverer| TP8S1| TREES_T100018873| UY3_02110| XELAEV_18033535mg| xmbp| Y1Q_003963| Y956_00776| Z169_01377| mbp

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