The Function of MARCKS
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
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Protein names
Recommended name:
Myristoylated alanine-rich C-kinase substrateShort name:
PKCSLAlternative name(s):
MARCKSProtein kinase C substrate, 80 kDa protein, light chain
80K-L protein
- RS7765004 (MARCKS) ??
- RS9488238 (MARCKS) ??
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Top Gene-Substance Interactions
MARCKS Interacts with These Diseases
| Disease | Score |
Substances That Increase MARCKS
| Substances | Interaction | Organism | Category |
Substances That Decrease MARCKS
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Regulation Of Insulin Secretion
- Actin Filament Organization
- Activation Of Phospholipase D Activity
- Brain Development
- Cell-Substrate Adhesion
- Intracellular Protein Transport
- Positive Regulation Of Dendritic Spine Morphogenesis
- Positive Regulation Of Glucose Import In Response To Insulin Stimulus
- Positive Regulation Of Protein Kinase C Activity
- Ventricular Cardiac Muscle Tissue Development