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  3. MARCKS

MARCKS (Myristoylated alanine rich protein kinase C substrate)

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The Function of MARCKS

MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

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Protein names

Recommended name:

Myristoylated alanine-rich C-kinase substrate

Short name:

PKCSL

Alternative name(s):

MARCKS
Protein kinase C substrate, 80 kDa protein, light chain
80K-L protein

MARCKS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7765004 (MARCKS) ??
  2. RS9488238 (MARCKS) ??

Top Gene-Substance Interactions

MARCKS Interacts with These Diseases

Disease Score

Substances That Increase MARCKS

Substances Interaction Organism Category

Substances That Decrease MARCKS

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun

Gene Pathways:

  • Metabolism

Molecular Function:

  • Actin Filament Binding
  • Calmodulin Binding
  • Phosphatidylserine Binding

Biological Processes:

  • Regulation Of Insulin Secretion
  • Actin Filament Organization
  • Activation Of Phospholipase D Activity
  • Brain Development
  • Cell-Substrate Adhesion
  • Intracellular Protein Transport
  • Positive Regulation Of Dendritic Spine Morphogenesis
  • Positive Regulation Of Glucose Import In Response To Insulin Stimulus
  • Positive Regulation Of Protein Kinase C Activity
  • Ventricular Cardiac Muscle Tissue Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Macs| 80k-l| 80K protein| ACAMP-81| KINC| Myristoylated alanine-rich C-kinase substrate| myristoylated alanine-rich C kinase substrate (MARCKS)| Myristoylated alanine-rich protein kinase C substrate| myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)| phosphomyristin| PKCSL| prkcsl| protein kinase C substrate 80 kDa protein| protein kinase C substrate, 80 kDa protein, light chain| UY3_04824| Y1Q_004811| marcks

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