Summary of MAPK8
The gene codes for a protein, mitogen-activated protein kinase 8. The kinase plays a role in UV radiation induced apoptosis. Studies of a mouse counterpart suggest that it plays an important function in T cell proliferation, apoptosis and differentiation. [R].
The Function of MAPK8
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Protein names
Recommended name:
Mitogen-activated protein kinase 8Short name:
MAPK 8Alternative name(s):
MAP kinase 8JNK-46
Stress-activated protein kinase 1c
SAPK1c
Stress-activated protein kinase JNK1
c-Jun N-terminal kinase 1
- RS10857561 (MAPK8) ??
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Top Gene-Substance Interactions
MAPK8 Interacts with These Diseases
| Disease | Score |
Substances That Increase MAPK8
| Substances | Interaction | Organism | Category |
Substances That Decrease MAPK8
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Immune System
- Apoptosis
- Insulin signaling pathway
- Type II diabetes mellitus
- Chagas disease (American trypanosomiasis)
- Tuberculosis
- Toxoplasmosis
- Pathways in cancer
- Epithelial cell signaling in Helicobacter pylori infection
- Toll-like receptor signaling pathway
- Neurotrophin signaling pathway
- Progesterone-mediated oocyte maturation
- TRAF6 Mediated Induction of proinflammatory cytokines
- Cell-Cell communication
- Osteoclast differentiation
- NOD-like receptor signaling pathway
- Fc epsilon RI signaling pathway
- Cellular responses to stress
- Wnt signaling pathway
- Colorectal cancer
- Adipocytokine signaling pathway
- Shigellosis
- MAPK signaling pathway
- Signal Transduction
- RIG-I-like receptor signaling pathway
- Protein processing in endoplasmic reticulum
- Pancreatic cancer
- Hepatitis C
- GnRH signaling pathway
Enzyme Regulation:
Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3.
Molecular Function:
- Atp Binding
- Enzyme Binding
- Histone Deacetylase Binding
- Histone Deacetylase Regulator Activity
- Jun Kinase Activity
- Protein Serine/Threonine Kinase Activity
Biological Processes:
- Cellular Response To Lipopolysaccharide
- Cellular Response To Mechanical Stimulus
- Fc-Epsilon Receptor Signaling Pathway
- Jnk Cascade
- Jun Phosphorylation
- Negative Regulation Of Apoptotic Process
- Peptidyl-Serine Phosphorylation
- Peptidyl-Threonine Phosphorylation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Cyclase Activity
- Positive Regulation Of Deacetylase Activity
- Positive Regulation Of Gene Expression
- Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
- Positive Regulation Of Protein Metabolic Process
- Protein Phosphorylation
- Regulation Of Circadian Rhythm
- Regulation Of Macroautophagy
- Regulation Of Protein Localization
- Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Response To Stress
- Response To Uv
- Rhythmic Process