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  3. MAPK8

MAPK8 (Mitogen-activated protein kinase 8)

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Summary of MAPK8

The gene codes for a protein, mitogen-activated protein kinase 8. The kinase plays a role in UV radiation induced apoptosis. Studies of a mouse counterpart suggest that it plays an important function in T cell proliferation, apoptosis and differentiation.  [R].

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The Function of MAPK8

JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Protein names

Recommended name:

Mitogen-activated protein kinase 8

Short name:

MAPK 8

Alternative name(s):

MAP kinase 8
JNK-46
Stress-activated protein kinase 1c
SAPK1c
Stress-activated protein kinase JNK1
c-Jun N-terminal kinase 1

MAPK8 SNPs

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  1. RS10857561 (MAPK8) ??

Top Gene-Substance Interactions

MAPK8 Interacts with These Diseases

Disease Score

Substances That Increase MAPK8

Substances Interaction Organism Category

Substances That Decrease MAPK8

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • c-Fos
  • AML1a

Gene Pathways:

  • Immune System
  • Apoptosis
  • Insulin signaling pathway
  • Type II diabetes mellitus
  • Chagas disease (American trypanosomiasis)
  • Tuberculosis
  • Toxoplasmosis
  • Pathways in cancer
  • Epithelial cell signaling in Helicobacter pylori infection
  • Toll-like receptor signaling pathway
  • Neurotrophin signaling pathway
  • Progesterone-mediated oocyte maturation
  • TRAF6 Mediated Induction of proinflammatory cytokines
  • Cell-Cell communication
  • Osteoclast differentiation
  • NOD-like receptor signaling pathway
  • Fc epsilon RI signaling pathway
  • Cellular responses to stress
  • Wnt signaling pathway
  • Colorectal cancer
  • Adipocytokine signaling pathway
  • Shigellosis
  • MAPK signaling pathway
  • Signal Transduction
  • RIG-I-like receptor signaling pathway
  • Protein processing in endoplasmic reticulum
  • Pancreatic cancer
  • Hepatitis C
  • GnRH signaling pathway

Enzyme Regulation:

Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3.

Molecular Function:

  • Atp Binding
  • Enzyme Binding
  • Histone Deacetylase Binding
  • Histone Deacetylase Regulator Activity
  • Jun Kinase Activity
  • Protein Serine/Threonine Kinase Activity

Biological Processes:

  • Cellular Response To Lipopolysaccharide
  • Cellular Response To Mechanical Stimulus
  • Fc-Epsilon Receptor Signaling Pathway
  • Jnk Cascade
  • Jun Phosphorylation
  • Negative Regulation Of Apoptotic Process
  • Peptidyl-Serine Phosphorylation
  • Peptidyl-Threonine Phosphorylation
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Cyclase Activity
  • Positive Regulation Of Deacetylase Activity
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
  • Positive Regulation Of Protein Metabolic Process
  • Protein Phosphorylation
  • Regulation Of Circadian Rhythm
  • Regulation Of Macroautophagy
  • Regulation Of Protein Localization
  • Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Response To Stress
  • Response To Uv
  • Rhythmic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_09169| AS27_02584| AS28_04483| c-jun NH2-terminal kinase| c-Jun N-terminal kinase 1| D623_10008765| GW7_11354| H920_04623| janus kinase 1| JNK| JNK1| JNK1A2| JNK1 beta1 protein kinase| JNK21B1/2| JNK-46| JUN N-terminal kinase| M959_03218| MAPK 8| MAP kinase 8| MDA_GLEAN10013122| mitogen-activated protein kinase 8 isoform alpha2| mitogen-activated protein kinase 8 isoform beta2| mitogen-activated protein kinase 8 isoform JNK1 alpha1| mitogen-activated protein kinase 8 isoform JNK1 alpha2| mitogen-activated protein kinase 8 isoform JNK1 beta1| mitogen-activated protein kinase 8 isoform JNK1 beta2| N300_07524| N301_10666| N302_13468| N303_09210| N305_11440| N306_13178| N307_06121| N308_09059| N310_06203| N311_12939| N312_10444| N320_02500| N321_05396| N322_06980| N324_08591| N325_00856| N327_04793| N328_08012| N330_03964| N333_06039| N335_01652| N336_12658| N339_08237| N340_12458| N341_11211| p54 gamma| PAL_GLEAN10004413| PANDA_014394| prkm8| protein kinase mitogen-activated 8| sapk1| SAPK1c| SAPK gamma| stress-activated protein kinase 1| stress-activated protein kinase 1c| stress-activated protein kinase JNK1| TREES_T100013923| UY3_15889| Y1Q_010487| Y956_01539| Z169_12792| mapk8

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