Summary of MAPK1
The gene codes for a protein, mitogen-activated protein kinase 1. It performs mechanistically distinct functions [R].
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The Function of MAPK1
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Protein names
Recommended name:
Mitogen-activated protein kinase 1Short name:
ERT1Alternative name(s):
MAP kinase 1MAPK 1
Extracellular signal-regulated kinase 2
ERK-2
MAP kinase isoform p42
p42-MAPK
Mitogen-activated protein kinase 2
MAP kinase 2
MAPK 2
- RS2283792 (MAPK1) ??
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Top Gene-Substance Interactions
MAPK1 Interacts with These Diseases
| Disease | Score |
Substances That Increase MAPK1
| Substances | Interaction | Organism | Category |
Substances That Decrease MAPK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Dorso-ventral axis formation
- Glioma
- Endometrial cancer
- Toll-like receptor signaling pathway
- Natural killer cell mediated cytotoxicity
- Colorectal cancer
- mTOR signaling pathway
- Adherens junction
- Prostate cancer
- B cell receptor signaling pathway
- TRAF6 Mediated Induction of proinflammatory cytokines
- Progesterone-mediated oocyte maturation
- Aldosterone-regulated sodium reabsorption
- Regulation of actin cytoskeleton
- Hemostasis
- Innate Immune System
- Shigellosis
- T cell receptor signaling pathway
- VEGF signaling pathway
- Tuberculosis
- TGF-beta signaling pathway
- Leishmaniasis
- Oocyte meiosis
- Toxoplasmosis
- MAPK signaling pathway
- Cellular responses to stress
- Alzheimer's disease
- Glutamatergic synapse
- Immune System
- Acute myeloid leukemia
- Pancreatic cancer
- Vascular smooth muscle contraction
- Melanoma
- Neuronal System
- Long-term potentiation
- Type II diabetes mellitus
- Neurotrophin signaling pathway
- Axon guidance
- Chemokine signaling pathway
- NOD-like receptor signaling pathway
- Renal cell carcinoma
- Fc epsilon RI signaling pathway
- Disease
- Hepatitis C
- Osteoclast differentiation
- GnRH signaling pathway
- Thyroid cancer
- Insulin signaling pathway
- Chagas disease (American trypanosomiasis)
- Pathways in cancer
- Melanogenesis
- Non-small cell lung cancer
- Prion diseases
- Long-term depression
- Bladder cancer
- Chronic myeloid leukemia
- Signal Transduction
Enzyme Regulation:
Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-185 and Tyr-187 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.
Molecular Function:
- Dna Binding
- Protein Serine/Threonine Kinase Activity
- Map Kinase Activity
- Atp Binding
- Rna Polymerase Ii Carboxy-Terminal Domain Kinase Activity
- Phosphatase Binding
- Identical Protein Binding
Biological Processes:
- Mapk Cascade
- Activation Of Mapk Activity
- Mapk Import Into Nucleus
- Transcription, Dna-Templated
- Protein Phosphorylation
- Apoptotic Process
- Chemotaxis
- Response To Stress
- Cellular Response To Dna Damage Stimulus
- Cell Cycle
- Signal Transduction
- Chemical Synaptic Transmission
- Axon Guidance
- Positive Regulation Of Cell Proliferation
- Fibroblast Growth Factor Receptor Signaling Pathway
- Response To Toxic Substance
- Positive Regulation Of Peptidyl-Threonine Phosphorylation
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Viral Process
- Peptidyl-Serine Phosphorylation
- Peptidyl-Threonine Phosphorylation
- Sensory Perception Of Pain
- Cytosine Metabolic Process
- Platelet Activation
- Regulation Of Ossification
- Positive Regulation Of Cell Migration
- Thyroid Gland Development
- Regulation Of Protein Stability
- Lipopolysaccharide-Mediated Signaling Pathway
- Positive Regulation Of Telomere Maintenance Via Telomerase
- Regulation Of Stress-Activated Mapk Cascade
- Mammary Gland Epithelial Cell Proliferation
- Fc-Epsilon Receptor Signaling Pathway
- Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
- Erbb Signaling Pathway
- Outer Ear Morphogenesis
- Response To Exogenous Dsrna
- Response To Estrogen
- Negative Regulation Of Cell Differentiation
- Positive Regulation Of Translation
- Positive Regulation Of Transcription, Dna-Templated
- Thymus Development
- T Cell Receptor Signaling Pathway
- B Cell Receptor Signaling Pathway
- Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Regulation Of Cytoskeleton Organization
- Positive Regulation Of Telomerase Activity
- Bergmann Glial Cell Differentiation
- Long-Term Synaptic Potentiation
- Face Development
- Jak-Stat Cascade Involved In Growth Hormone Signaling Pathway
- Lung Morphogenesis
- Trachea Formation
- Labyrinthine Layer Blood Vessel Development
- Cardiac Neural Crest Cell Development Involved In Heart Development
- Erk1 And Erk2 Cascade
- Response To Epidermal Growth Factor
- Caveolin-Mediated Endocytosis
- Regulation Of Golgi Inheritance
- Cellular Response To Granulocyte Macrophage Colony-Stimulating Factor Stimulus
- Regulation Of Cellular Response To Heat
- Positive Regulation Of Telomere Capping
- Regulation Of Early Endosome To Late Endosome Transport
Drug Bank:
- Isoprenaline
- Arsenic Trioxide