The Function of MAP3K7
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.
Protein names
Recommended name:
Mitogen-activated protein kinase kinase kinase 7Alternative name(s):
Transforming growth factor-beta-activated kinase 1TGF-beta-activated kinase 1
- RS806276 (MAP3K7) ??
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Top Gene-Substance Interactions
MAP3K7 Interacts with These Diseases
| Disease | Score |
Substances That Increase MAP3K7
| Substances | Interaction | Organism | Category |
Substances That Decrease MAP3K7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
Gene Pathways:
- Immune System
- MAPK signaling pathway
- Signal Transduction
- Wnt signaling pathway
- Measles
- RIG-I-like receptor signaling pathway
- Toll-like receptor signaling pathway
- Adherens junction
- T cell receptor signaling pathway
- NOD-like receptor signaling pathway
- Osteoclast differentiation
- Toxoplasmosis
- TRAF6 Mediated Induction of proinflammatory cytokines
- Leishmaniasis
Enzyme Regulation:
Activated by proinflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation. Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 promotes activation through autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C dephosphorylation leads to inactivation.
Molecular Function:
- Atp Binding
- Magnesium Ion Binding
- Map Kinase Kinase Kinase Activity
- Protein Serine/Threonine Kinase Activity
- Scaffold Protein Binding
Biological Processes:
- Activation Of Mapk Activity
- Activation Of Mapkk Activity
- Activation Of Nf-Kappab-Inducing Kinase Activity
- Apoptotic Process
- Fc-Epsilon Receptor Signaling Pathway
- Histone H3 Acetylation
- I-Kappab Kinase/Nf-Kappab Signaling
- I-Kappab Phosphorylation
- Jnk Cascade
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Nucleotide-Binding Oligomerization Domain Containing Signaling Pathway
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Interleukin-2 Production
- Positive Regulation Of Jun Kinase Activity
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Positive Regulation Of T Cell Activation
- Positive Regulation Of T Cell Cytokine Production
- Stimulatory C-Type Lectin Receptor Signaling Pathway
- Stress-Activated Mapk Cascade
- T Cell Receptor Signaling Pathway
- Transcription, Dna-Templated
- Transforming Growth Factor Beta Receptor Signaling Pathway
- Wnt Signaling Pathway, Calcium Modulating Pathway