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  3. MAP3K3

MAP3K3 (Mitogen-activated protein kinase kinase kinase 3)

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Summary of MAP3K3

The gene codes for a protein, mitogen-activated protein kinase kinase kinase 3. The protein regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively. It does not regulate the p38 pathway [R].

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The Function of MAP3K3

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Protein names

Recommended name:

Mitogen-activated protein kinase kinase kinase 3

Short name:

MEKK 3

Alternative name(s):

MAPK/ERK kinase kinase 3
MEK kinase 3

MAP3K3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11658329 (MAP3K3) ??
  2. RS3785574 (MAP3K3) ??
  3. RS7209435 (MAP3K3) ??

Top Gene-Substance Interactions

Substances That Increase MAP3K3

Substances Interaction Organism Category

Substances That Decrease MAP3K3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1

Gene Pathways:

  • Immune System
  • MAPK signaling pathway
  • Neurotrophin signaling pathway
  • GnRH signaling pathway

Enzyme Regulation:

Activated by phosphorylation on Thr-530.

Molecular Function:

  • Atp Binding
  • Map Kinase Kinase Kinase Activity
  • Metal Ion Binding

Biological Processes:

  • Blood Vessel Development
  • Intracellular Signal Transduction
  • Mapk Cascade
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of P38mapk Cascade
  • Protein Autophosphorylation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14237| Anapl_11769| AS27_06538| AS28_04746| CB1_000313021| D623_10031100| H920_20510| M91_15252| MAP/ERK kinase kinase 3| MAPK/ERK kinase kinase 3| MAPKKK3| MEKK3| MEKK 3| MEK kinase 3| mitogen activated protein kinase kinase kinase 3| N302_11304| N310_09112| N320_04698| N321_07831| N324_05548| N327_05455| N331_00831| N334_11457| N336_03491| N339_13228| N340_05593| N341_07313| PAL_GLEAN10014893| PANDA_013942| TREES_T100002770| UY3_09015| WD-repeat protein| Y1Q_031175| Y956_09921| Z169_00127| map3k3

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