Summary of MAP3K3
The gene codes for a protein, mitogen-activated protein kinase kinase kinase 3. The protein regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively. It does not regulate the p38 pathway [R].
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The Function of MAP3K3
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
Protein names
Recommended name:
Mitogen-activated protein kinase kinase kinase 3Short name:
MEKK 3Alternative name(s):
MAPK/ERK kinase kinase 3MEK kinase 3
- RS11658329 (MAP3K3) ??
- RS3785574 (MAP3K3) ??
- RS7209435 (MAP3K3) ??
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Top Gene-Substance Interactions
Substances That Increase MAP3K3
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Substances That Decrease MAP3K3
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Activated by phosphorylation on Thr-530.
Molecular Function:
Biological Processes:
- Blood Vessel Development
- Intracellular Signal Transduction
- Mapk Cascade
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of P38mapk Cascade
- Protein Autophosphorylation