The Function of MAP1LC3B
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Protein names
Recommended name:
Microtubule-associated proteins 1A/1B light chain 3BShort name:
MAP1A/MAP1B LC3 BAlternative name(s):
Autophagy-related protein LC3 BAutophagy-related ubiquitin-like modifier LC3 B
MAP1 light chain 3-like protein 2
MAP1A/MAP1B light chain 3 B
Microtubule-associated protein 1 light chain 3 beta
Top Gene-Substance Interactions
MAP1LC3B Interacts with These Diseases
| Disease | Score |
Substances That Increase MAP1LC3B
| Substances | Interaction | Organism | Category |
Substances That Decrease MAP1LC3B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.
Caution:
PubMed:12740394 has shown that the protein is cleaved at Lys-122 but PubMed:15355958 has shown that the cleavage site is at Gly-120 as in other mammalian orthologs.
Molecular Function:
Biological Processes:
- Autophagosome Assembly
- Cellular Response To Nitrogen Starvation
- Macroautophagy
- Regulation Of Mitophagy