• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. MAP1LC3B

MAP1LC3B (Microtubule associated protein 1 light chain 3 beta)

Loading...

The Function of MAP1LC3B

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Microtubule-associated proteins 1A/1B light chain 3B

Short name:

MAP1A/MAP1B LC3 B

Alternative name(s):

Autophagy-related protein LC3 B
Autophagy-related ubiquitin-like modifier LC3 B
MAP1 light chain 3-like protein 2
MAP1A/MAP1B light chain 3 B
Microtubule-associated protein 1 light chain 3 beta

Top Gene-Substance Interactions

MAP1LC3B Interacts with These Diseases

Disease Score

Substances That Increase MAP1LC3B

Substances Interaction Organism Category

Substances That Decrease MAP1LC3B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Arnt
  • ITF-2
  • Tal-1beta
  • SREBP-1a
  • SREBP-1b
  • Bach2
  • E47
  • Tal-1

Tissue specificity:

Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.

Caution:

PubMed:12740394 has shown that the protein is cleaved at Lys-122 but PubMed:15355958 has shown that the cleavage site is at Gly-120 as in other mammalian orthologs.

Molecular Function:

  • Microtubule Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Autophagosome Assembly
  • Cellular Response To Nitrogen Starvation
  • Macroautophagy
  • Regulation Of Mitophagy
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Microtubule-associated proteins 1A/1B light chain 3B| RNA-dependent DNA polymerase| A306_01717| Anapl_14361| AS27_11354| AS28_10212| Atg8| ATG8F| autophagy-related protein LC3 B| autophagy-related ubiquitin-like modifier LC3 B| CB1_000589038| LC| Lc3| LC3B| M959_05401| MAP1A/1BLC3| MAP1A/1B light chain 3 B| MAP1A/MAP1B LC3 B| MAP1A/MAP1B light chain 3 B| Map1lc3| MAP1LC3B-a| MAP1 light chain 3-like protein 2| MDA_GLEAN10022619| microtubule-associated protein 1 light chain 3 beta| microtubule-associated protein light chain 3| microtubule-associated proteins 1A/1B light chain 3| microtubule-associated proteins 1A/1B light chain 3B-like protein| mlp3b| Mpl3| N300_09174| N301_00331| N302_09628| N303_10631| N305_04807| N306_01161| N307_03664| N308_10225| N309_03581| N320_01410| N322_04176| N324_00887| N329_04835| N332_13990| N334_07976| N339_08501| N340_01266| PAL_GLEAN10025627| PANDA_001230| putative microtubule-associated protein 1 light chain 3 beta variant 1| UY3_06583| Y1Q_022406| Y956_11005| Z169_10251| zbs559| map1lc3b

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved