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  3. MAOB

MAOB (Monoamine oxidase B)

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Summary of MAOB

MAOB (monoamine oxidase B) encodes a protein that plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system (R). 

It is associated with higher risk for Parkinson's and Alzheimer diseases (R, R). 

It's better to have this gene decreased most of the time.
0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Amine oxidase [flavin-containing] B

Short name:

MAO-B

Alternative name(s):

Monoamine oxidase type B

MAOB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1799836 (MAOB) ??
  2. RS2283729 (MAOB) ??
  3. RS3027409 (MAOB) ??
  4. RS3027452 (MAOB) ??

Top Gene-Substance Interactions

MAOB Interacts with These Diseases

Disease Score

Substances That Increase MAOB

Substances Interaction Organism Category

Substances That Decrease MAOB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • AP-1
  • c-Jun
  • Sp1
  • AREB6

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Tryptophan metabolism
  • Arginine and proline metabolism
  • Glycine, serine and threonine metabolism
  • Drug metabolism - cytochrome P450
  • Tyrosine metabolism
  • Histidine metabolism
  • Phenylalanine metabolism

Molecular Function:

  • Electron Carrier Activity
  • Flavin Adenine Dinucleotide Binding
  • Primary Amine Oxidase Activity

Biological Processes:

  • Dopamine Catabolic Process
  • Hydrogen Peroxide Biosynthetic Process
  • Negative Regulation Of Serotonin Secretion
  • Neurotransmitter Catabolic Process
  • Positive Regulation Of Dopamine Metabolic Process
  • Response To Aluminum Ion
  • Response To Corticosterone
  • Response To Ethanol
  • Response To Lipopolysaccharide
  • Response To Selenium Ion
  • Response To Toxic Substance
  • Substantia Nigra Development

Drug Bank:

  • Ephedra
  • Flavin Adenine Dinucleotide
  • Amantadine
  • Dopamine
  • Furazolidone
  • Isocarboxazid
  • Linezolid
  • Methamphetamine
  • Moclobemide
  • Pargyline
  • Phenelzine
  • Phentermine
  • Procaine
  • Selegiline
  • Sertraline
  • Tranylcypromine
  • Zonisamide
  • Nicotine
  • Amphetamine
  • Nandrolone Decanoate
  • Rasagiline
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| adrenalin oxidase| amine oxidase [flavin-containing] B| amine oxidase (flavin-containing)-like protein| CB1_002113003| GW7_12667| H920_19377| I79_018567| M91_08192| MAOA| MAO-B| MAO, brain| MAO, platelet| MDA_GLEAN10007947| monoamine oxidase A| monoamine oxidase type B| N308_06061| N321_13256| N330_11292| PAL_GLEAN10003586| PANDA_011988| TREES_T100018537| tyramine oxidase| UY3_11421| Y1Q_022224| maob

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