Summary of MAOB

The MAOB gene encodes an enzyme called monoamine oxidase B (MAO-B) [R].

MAO-B is an enzyme that helps break down the chemical messengers (neurotransmitters) serotonin, dopamine, and norepinephrine. These neurotransmitters are collectively called monoamines [R].

Several psychoactive medications target MAO-B (and the closely related MAO-A). These are called monoamine oxidase inhibitors, or MAOIs. The first antidepressants were MAOIs, but they have broadly been surpassed and replaced by drugs with other mechanisms, such as SSRIs [R, R].

Variants in MAOB have been linked to [R, R, R, R, R, R]:

  • Essential hypertension
  • Antidepressant response
  • Psychotic disorders
  • Parkinson’s disease
  • Schizophrenia
  • Fatigue
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Protein names

Recommended name:

Amine oxidase [flavin-containing] B

Short name:

MAO-B

Alternative name(s):

Monoamine oxidase type B

Top Gene-Substance Interactions

MAOB Interacts with These Diseases

Substances That Increase MAOB

Substances That Decrease MAOB

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical