The Function of MAD2L1
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
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Protein names
Recommended name:
Mitotic spindle assembly checkpoint protein MAD2AAlternative name(s):
HsMAD2Mitotic arrest deficient 2-like protein 1
MAD2-like protein 1
- RS1493682 (MAD2L1) ??
- RS1845344 (MAD2L1) ??
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Top Gene-Substance Interactions
MAD2L1 Interacts with These Diseases
| Disease | Score |
Substances That Increase MAD2L1
| Substances | Interaction | Organism | Category |
Substances That Decrease MAD2L1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Mitotic Sister Chromatid Segregation
- Sister Chromatid Cohesion
- Mitotic Cell Cycle Checkpoint
- Mitotic Spindle Assembly Checkpoint
- Anaphase-Promoting Complex-Dependent Catabolic Process
- Negative Regulation Of Protein Catabolic Process
- Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Apoptotic Process
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Mitotic Cell Cycle
- Cell Division
- Negative Regulation Of Ubiquitin-Protein Ligase Activity Involved In Mitotic Cell Cycle
- Positive Regulation Of Ubiquitin-Protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
- Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
- Negative Regulation Of Ubiquitin Protein Ligase Activity