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  3. MAD2L1

MAD2L1 (MAD2 mitotic arrest deficient-like 1 (yeast))

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The Function of MAD2L1

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

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Protein names

Recommended name:

Mitotic spindle assembly checkpoint protein MAD2A

Alternative name(s):

HsMAD2
Mitotic arrest deficient 2-like protein 1
MAD2-like protein 1

MAD2L1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1493682 (MAD2L1) ??
  2. RS1845344 (MAD2L1) ??

Top Gene-Substance Interactions

MAD2L1 Interacts with These Diseases

Disease Score

Substances That Increase MAD2L1

Substances Interaction Organism Category

Substances That Decrease MAD2L1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pax-3
  • ARP-1
  • Meis-1
  • HSF2
  • Nkx3-1
  • Meis-1b

Gene Pathways:

  • Oocyte meiosis
  • Progesterone-mediated oocyte maturation
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • APC-Cdc20 mediated degradation of Nek2A

Molecular Function:

  • Protein Homodimerization Activity
  • Identical Protein Binding

Biological Processes:

  • Anaphase-Promoting Complex-Dependent Catabolic Process
  • Cell Division
  • Mitotic Cell Cycle Checkpoint
  • Mitotic Sister Chromatid Segregation
  • Mitotic Spindle Assembly Checkpoint
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Mitotic Cell Cycle
  • Negative Regulation Of Protein Catabolic Process
  • Negative Regulation Of Ubiquitin Protein Ligase Activity
  • Negative Regulation Of Ubiquitin-Protein Ligase Activity Involved In Mitotic Cell Cycle
  • Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
  • Positive Regulation Of Ubiquitin-Protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
  • Sister Chromatid Cohesion
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_08738| CB1_000816008| D623_10002958| EH28_23985| H920_01814| HSMAD2| M959_03886| MAD2| MAD2-like 1| MAD2-like protein 1| MAD2 (mitotic arrest deficient, homolog)-like 1| MAD2 mitotic arrest deficient-like 1| MAD2 (mitotic arrest deficient, yeast, homolog)-like 1| md2l1| MDA_GLEAN10013420| mitotic arrest deficient 2| mitotic arrest deficient 2-like protein 1| mitotic arrest deficient, yeast, homolog-like 1| mitotic spindle assembly checkpoint protein MAD2A| mitotic spindle assembly checkpoint protein MAD2A-like| mitotic spindle assembly checkpoint protein MAD2A-like protein| N300_01763| N301_15494| N302_04852| N303_12226| N305_11091| N306_04434| N307_15130| N308_08425| N309_01246| N310_10240| N311_09152| N312_10424| N320_10366| N321_12232| N324_07201| N325_10398| N328_10406| N329_00201| N330_06677| N331_10730| N332_00368| N334_00594| N335_00225| N336_00206| N339_10527| N340_11034| N341_07529| PAL_GLEAN10013916| PANDA_012212| spindle assembly checkpoint protein Mad2| TREES_T100015051| XMad2| Y1Q_004163| Y956_09567| Z169_08395| mad2l1

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