The Function of MACF1
Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.
Protein names
Recommended name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Short name:
ABP620Alternative name(s):
620 kDa actin-binding proteinActin cross-linking family protein 7
Macrophin-1
Trabeculin-alpha
- RS72634501 (MACF1) ??
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Top Gene-Substance Interactions
Substances That Increase MACF1
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Substances That Decrease MACF1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 2 is ubiquitously expressed. Isoform 1 is expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4 is expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.
Molecular Function:
- Actin Binding
- Actin Filament Binding
- Atpase Activity
- Cadherin Binding Involved In Cell-Cell Adhesion
- Calcium Ion Binding
- Poly(A) Rna Binding
Biological Processes:
- Golgi To Plasma Membrane Protein Transport
- Positive Regulation Of Axon Extension
- Positive Regulation Of Wnt Signaling Pathway
- Regulation Of Epithelial Cell Migration
- Regulation Of Focal Adhesion Assembly
- Regulation Of Microtubule-Based Process
- Wnt Signaling Pathway
- Wound Healing