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  3. MACF1

MACF1 (Microtubule-actin crosslinking factor 1)

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The Function of MACF1

Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.

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Protein names

Recommended name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Short name:

ABP620

Alternative name(s):

620 kDa actin-binding protein
Actin cross-linking family protein 7
Macrophin-1
Trabeculin-alpha

MACF1 SNPs

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  1. RS72634501 (MACF1) ??

Top Gene-Substance Interactions

Substances That Increase MACF1

Substances Interaction Organism Category

Substances That Decrease MACF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Isoform 2 is ubiquitously expressed. Isoform 1 is expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4 is expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.

Molecular Function:

  • Actin Binding
  • Actin Filament Binding
  • Atpase Activity
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Calcium Ion Binding
  • Poly(A) Rna Binding

Biological Processes:

  • Golgi To Plasma Membrane Protein Transport
  • Positive Regulation Of Axon Extension
  • Positive Regulation Of Wnt Signaling Pathway
  • Regulation Of Epithelial Cell Migration
  • Regulation Of Focal Adhesion Assembly
  • Regulation Of Microtubule-Based Process
  • Wnt Signaling Pathway
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Microtubule-actin cross-linking factor 1| Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5| 620 kDa actin binding protein| A306_13031| ABP620| Acf7| Aclp7| actin cross-linking family 7| actin cross-linking family protein 7| actin-crosslinking protein| actin-crosslinking protein 7| AS27_13923| CB1_000884063| D623_10028944| dystonin| I79_012206| Kiaa0754| M91_13261| macf| macrophin 1 isoform| microfilament and actin filament cross-linker protein| microtubule-actin cross-linking factor 1, isoforms 1/2/3/5-like protein| microtubule-actin cross-linking factor 1-like| N330_06223| OFC4| PAL_GLEAN10014911| PANDA_017334| R74989| trabeculin alpha| trabeculin-alpha| UY3_14469| Y1Q_030645| Z169_00244| macf1

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