The Function of MACF1

Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Short name:

ABP620

Alternative name(s):

620 kDa actin-binding protein
Actin cross-linking family protein 7
Macrophin-1
Trabeculin-alpha

Top Gene-Substance Interactions

Substances That Increase MACF1

Substances That Decrease MACF1

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical