The Function of LY96
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).
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Protein names
Recommended name:
Lymphocyte antigen 96Alternative name(s):
Ly-96ESOP-1
Protein MD-2
- RS10504554 (LY96) ??
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Top Gene-Substance Interactions
LY96 Interacts with These Diseases
| Disease | Score |
Substances That Increase LY96
| Substances | Interaction | Organism | Category |
Substances That Decrease LY96
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Apoptotic Signaling Pathway
- Cell Surface Receptor Signaling Pathway
- Cellular Defense Response
- Detection Of Lipopolysaccharide
- I-Kappab Kinase/Nf-Kappab Signaling
- Inflammatory Response
- Innate Immune Response
- Myd88-Dependent Toll-Like Receptor Signaling Pathway
- Myd88-Independent Toll-Like Receptor Signaling Pathway
- Necroptotic Process
- Negative Regulation Of Myd88-Independent Toll-Like Receptor Signaling Pathway
- Positive Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
- Positive Regulation Of Tumor Necrosis Factor Production
- Response To Lipopolysaccharide
- Toll-Like Receptor 4 Signaling Pathway
- Trif-Dependent Toll-Like Receptor Signaling Pathway