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  2. Genes
  3. LY96

LY96 (Lymphocyte antigen 96)

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The Function of LY96

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).

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Protein names

Recommended name:

Lymphocyte antigen 96

Alternative name(s):

Ly-96
ESOP-1
Protein MD-2

LY96 SNPs

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  1. RS10504554 (LY96) ??

Top Gene-Substance Interactions

LY96 Interacts with These Diseases

Disease Score

Substances That Increase LY96

Substances Interaction Organism Category

Substances That Decrease LY96

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun

Gene Pathways:

  • Immune System
  • Toll-like receptor signaling pathway
  • Pathogenic Escherichia coli infection
  • Toxoplasmosis

Molecular Function:

  • Coreceptor Activity
  • Lipopolysaccharide Receptor Activity

Biological Processes:

  • Apoptotic Signaling Pathway
  • Cell Surface Receptor Signaling Pathway
  • Cellular Defense Response
  • Detection Of Lipopolysaccharide
  • I-Kappab Kinase/Nf-Kappab Signaling
  • Inflammatory Response
  • Innate Immune Response
  • Myd88-Dependent Toll-Like Receptor Signaling Pathway
  • Myd88-Independent Toll-Like Receptor Signaling Pathway
  • Necroptotic Process
  • Negative Regulation Of Myd88-Independent Toll-Like Receptor Signaling Pathway
  • Positive Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
  • Positive Regulation Of Tumor Necrosis Factor Production
  • Response To Lipopolysaccharide
  • Toll-Like Receptor 4 Signaling Pathway
  • Trif-Dependent Toll-Like Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

null| Anapl_06192| AS27_13122| AS28_00413| EGK_19050| ESOP-1| GW7_21389| H920_04563| LPS co-receptor MD-2| Ly-96| M959_14380| Md2| MD-2| MD-2 protein| MDA_GLEAN10021997| myeloid differentiation factor-2| myeloid differentiation protein-2| N300_12138| N301_02726| N302_13817| N303_14746| N305_00348| N306_05229| N307_03348| N308_13827| N309_14153| N310_07757| N312_04701| N321_09232| N322_10604| N324_07632| N325_05456| N326_02156| N327_10965| N329_05109| N330_01172| N331_06147| N332_09757| N333_02849| N334_12643| N335_12324| N336_12096| N339_07665| N340_11903| N341_12732| PAL_GLEAN10019353| PANDA_021279| Protein MD-2| TMEM70| transmembrane protein 70| Y956_14783| Z169_05573| ly96

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