The Function of LTF
Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.
Protein names
Recommended name:
LactotransferrinAlternative name(s):
LactoferrinGrowth-inhibiting protein 12
Talalactoferrin
Lfcin-H
Top Gene-Substance Interactions
LTF Interacts with These Diseases
| Disease | Score |
Substances That Increase LTF
| Substances | Interaction | Organism | Category |
Substances That Decrease LTF
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.
Gene Pathways:
Molecular Function:
- Dna Binding
- Serine-Type Endopeptidase Activity
- Iron Ion Binding
- Heparin Binding
- Protein Serine/Threonine Kinase Activator Activity
Biological Processes:
- Ossification
- Regulation Of Cytokine Production
- Retina Homeostasis
- Innate Immune Response In Mucosa
- Transcription, Dna-Templated
- Ion Transport
- Humoral Immune Response
- Antibacterial Humoral Response
- Antifungal Humoral Response
- Negative Regulation Of Lipopolysaccharide-Mediated Signaling Pathway
- Regulation Of Tumor Necrosis Factor Production
- Negative Regulation Of Atpase Activity
- Iron Assimilation By Chelation And Transport
- Positive Regulation Of Osteoblast Proliferation
- Positive Regulation Of Toll-Like Receptor 4 Signaling Pathway
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Cellular Protein Metabolic Process
- Negative Regulation By Host Of Viral Process
- Negative Regulation Of Viral Genome Replication
- Cell Redox Homeostasis
- Positive Regulation Of Osteoblast Differentiation
- Negative Regulation Of Viral Process
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Bone Morphogenesis
- Positive Regulation Of Protein Serine/Threonine Kinase Activity
- Positive Regulation Of Bone Mineralization Involved In Bone Maturation
- Negative Regulation Of Single-Species Biofilm Formation In Or On Host Organism
- Positive Regulation Of Chondrocyte Proliferation
- Negative Regulation Of Tumor Necrosis Factor (Ligand) Superfamily Member 11 Production
- Negative Regulation Of Osteoclast Development