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  3. LTBP1

LTBP1 (Latent transforming growth factor beta binding protein 1)

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Summary of LTBP1

The gene codes for a protein, latent transforming growth factor beta binding protein 1. It is on chromosome 2 [R].

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The Function of LTBP1

May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).

Protein names

Recommended name:

Latent-transforming growth factor beta-binding protein 1

Short name:

LTBP-1

Alternative name(s):

Transforming growth factor beta-1-binding protein 1
TGF-beta1-BP-1

LTBP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1545552 (LTBP1) ??
  2. RS3769528 (LTBP1) ??
  3. RS41464348 (LTBP1) ??
  4. RS542631 (LTBP1) ??
  5. RS6714546 (LTBP1) ??

Top Gene-Substance Interactions

LTBP1 Interacts with These Diseases

Disease Score

Substances That Increase LTBP1

Substances Interaction Organism Category

Substances That Decrease LTBP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • c-Jun
  • FOXO3b

Tissue specificity:

Expressed in the aorta (at protein level). Isoform Long is found in fibroblasts.

Gene Pathways:

  • TGF-beta signaling pathway
  • Extracellular matrix organization

Molecular Function:

  • Calcium Ion Binding
  • Microfibril Binding
  • Transforming Growth Factor Beta-Activated Receptor Activity
  • Transforming Growth Factor Beta Binding

Biological Processes:

  • Aorta Development
  • Coronary Vasculature Development
  • Sequestering Of Tgfbeta In Extracellular Matrix
  • Ventricular Septum Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 9830146M04| A306_01019| AS27_08637| AS28_05152| b2b1000Clo| CB1_000749007| D623_10019003| H920_01412| I79_009100| LanC (bacterial lantibiotic synthetase component C)-like 1| latent TGF beta binding protein| latent TGFbeta binding protein| latent-transforming growth factor beta-binding protein 1| latent-transforming growth factor beta-binding protein 1 isoform LTBP-1S| latent transforming growth factor beta binding protein 1L| latent transforming growth factor binding protein 1| LTBP-1| Ltbp1L| LTGF-1| M91_20396| M959_11268| MDA_GLEAN10025481| N300_12222| N301_13712| N302_14565| N305_05943| N306_08920| N308_06134| N310_01642| N311_03316| N312_04964| N320_08468| N321_02015| N325_11664| N327_09269| N330_12858| N331_02527| N332_14412| N335_06645| N339_00937| N340_10877| PAL_GLEAN10020320| PANDA_012310| Tgfb| TGFbBP1| TGF-beta-1-BP-1| TGF-beta1-BP-1| transforming growth factor beta-1-binding protein 1| transforming growth factor beta-1-masking protein large subunit| transforming growth factor-beta (TGF-beta) masking protein large subunit| TREES_T100014490| UY3_18381| Y1Q_002647| Y956_16423| Z169_12461| ltbp1

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