Summary of LTBP1
The gene codes for a protein, latent transforming growth factor beta binding protein 1. It is on chromosome 2 [R].
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The Function of LTBP1
May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
Protein names
Recommended name:
Latent-transforming growth factor beta-binding protein 1Short name:
LTBP-1Alternative name(s):
Transforming growth factor beta-1-binding protein 1TGF-beta1-BP-1
- RS1545552 (LTBP1) ??
- RS3769528 (LTBP1) ??
- RS41464348 (LTBP1) ??
- RS542631 (LTBP1) ??
- RS6714546 (LTBP1) ??
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Top Gene-Substance Interactions
LTBP1 Interacts with These Diseases
| Disease | Score |
Substances That Increase LTBP1
| Substances | Interaction | Organism | Category |
Substances That Decrease LTBP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the aorta (at protein level). Isoform Long is found in fibroblasts.
Gene Pathways:
Molecular Function:
- Transforming Growth Factor Beta-Activated Receptor Activity
- Calcium Ion Binding
- Transforming Growth Factor Beta Binding
- Microfibril Binding
Biological Processes:
- Ventricular Septum Development
- Sequestering Of Tgfbeta In Extracellular Matrix
- Aorta Development
- Coronary Vasculature Development