The Function of LTB4R
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
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Protein names
Recommended name:
Leukotriene B4 receptor 1Short name:
P2Y7Alternative name(s):
LTB4-R 1LTB4-R1
Chemoattractant receptor-like 1
G-protein coupled receptor 16
P2Y purinoceptor 7
Top Gene-Substance Interactions
LTB4R Interacts with These Diseases
| Disease | Score |
Substances That Increase LTB4R
| Substances | Interaction | Organism | Category |
Substances That Decrease LTB4R
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.
Gene Pathways:
Molecular Function:
- G-Protein Coupled Peptide Receptor Activity
- Leukotriene B4 Receptor Activity
- Leukotriene Receptor Activity
- Nucleotide Binding
Biological Processes:
- G-Protein Coupled Receptor Signaling Pathway
- Immune Response
- Inflammatory Response
- Movement Of Cell Or Subcellular Component
- Muscle Contraction
- Neuropeptide Signaling Pathway
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway