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  3. LTB

LTB (Lymphotoxin beta)

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The Function of LTB

Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

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Protein names

Recommended name:

Lymphotoxin-beta

Short name:

TNF-C

Alternative name(s):

LT-beta
Tumor necrosis factor C
Tumor necrosis factor ligand superfamily member 3

Top Gene-Substance Interactions

Substances That Increase LTB

Substances Interaction Organism Category

Substances That Decrease LTB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Myc

Tissue specificity:

Spleen and thymus.

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Rheumatoid arthritis

Molecular Function:

  • Receptor Binding

Biological Processes:

  • Cell-Cell Signaling
  • Gene Expression
  • Immune Response
  • Lymph Node Development
  • Positive Regulation Of Interleukin-12 Biosynthetic Process
  • Signal Transduction
  • Skin Development
  • Tumor Necrosis Factor-Mediated Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p33| CB1_000383017| LT-b| LTbeta| LT-beta| lymphotoxin B| Lymphotoxin-beta| lymphotoxin-beta-like| lymphotoxin-beta-like protein| lymphotoxin beta (TNF superfamily, member 3)| M91_10753| PAL_GLEAN10001097| PANDA_020418| tnfc| TNF-C| Tnfsf3| TNF superfamily member 3| TNLG1C| TREES_T100017806| Tumor necrosis factor C| tumor necrosis factor ligand 1c| tumor necrosis factor ligand superfamily member 3| xltb| ltb

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