The Function of LTA
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
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Protein names
Recommended name:
Lymphotoxin-alphaAlternative name(s):
LT-alphaTNF-beta
Tumor necrosis factor ligand superfamily member 1
- RS1799964 (LTA) ??
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Top Gene-Substance Interactions
LTA Interacts with These Diseases
| Disease | Score |
Substances That Increase LTA
| Substances | Interaction | Organism | Category |
Substances That Decrease LTA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Apoptotic Process
- Cell-Cell Signaling
- Defense Response To Gram-Positive Bacterium
- Humoral Immune Response
- Lymph Node Development
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of Growth Of Symbiont In Host
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus
- Positive Regulation Of Glial Cell Proliferation
- Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
- Positive Regulation Of Interferon-Gamma Production
- Response To Hypoxia
- Response To Lipopolysaccharide
- Response To Nutrient
- Signal Transduction
- Tumor Necrosis Factor-Mediated Signaling Pathway
Drug Bank:
- Etanercept