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  3. LTA

LTA (Lymphotoxin alpha)

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The Function of LTA

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

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Protein names

Recommended name:

Lymphotoxin-alpha

Alternative name(s):

LT-alpha
TNF-beta
Tumor necrosis factor ligand superfamily member 1

LTA SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1799964 (LTA) ??

Top Gene-Substance Interactions

LTA Interacts with These Diseases

Disease Score

Substances That Increase LTA

Substances Interaction Organism Category

Substances That Decrease LTA

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • GR
  • GR-alpha
  • GR-beta
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • Brachyury

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Type I diabetes mellitus

Molecular Function:

  • Receptor Binding

Biological Processes:

  • Apoptotic Process
  • Cell-Cell Signaling
  • Defense Response To Gram-Positive Bacterium
  • Humoral Immune Response
  • Lymph Node Development
  • Negative Regulation Of Fibroblast Proliferation
  • Negative Regulation Of Growth Of Symbiont In Host
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus
  • Positive Regulation Of Glial Cell Proliferation
  • Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
  • Positive Regulation Of Interferon-Gamma Production
  • Response To Hypoxia
  • Response To Lipopolysaccharide
  • Response To Nutrient
  • Signal Transduction
  • Tumor Necrosis Factor-Mediated Signaling Pathway

Drug Bank:

  • Etanercept
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ATP-binding cassette, sub-family F (GCN20), member 1| CB1_000383015| EGK_14704| GW7_04771| hlb382| LT| LT-a| LT-[a]| LT[a]| LTalpha| LT-alpha| Ltx| lymphotoxin A| lymphotoxin-alpha| lymphotoxin-alpha-like protein| lymphotoxin alpha (TNF superfamily, member 1)| M91_10751| MDA_GLEAN10005613| PAL_GLEAN10001099| PANDA_020420| tnfb| TNF beta| TNF-beta| TNF-N| tnfsf1| Tnfsf1b| TNF superfamily, member 1| TNLG1E| TREES_T100017815| tumor necrosis factor beta| tumor necrosis factor ligand 1e| tumor necrosis factor ligand superfamily member 1| tumour necrosis factor beta| UY3_00750| lta

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