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  3. LRRFIP1

LRRFIP1 (LRR binding FLII interacting protein 1)

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The Function of LRRFIP1

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

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Protein names

Recommended name:

Leucine-rich repeat flightless-interacting protein 1

Alternative name(s):

LRR FLII-interacting protein 1
GC-binding factor 2
TAR RNA-interacting protein

LRRFIP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11680012 (LRRFIP1) ??

Top Gene-Substance Interactions

Substances That Increase LRRFIP1

Substances Interaction Organism Category

Substances That Decrease LRRFIP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • p300

Tissue specificity:

Ubiquitously expressed.

Gene Pathways:

  • Disease
  • Immune System

Developmental stage:

Widely expressed in fetal tissues.

Molecular Function:

  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Dna Binding
  • Double-Stranded Rna Binding
  • Protein Homodimerization Activity

Biological Processes:

  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Nf-Kappab Transcription Factor Activity
  • Positive Regulation Of Type I Interferon Production
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GCF2| Anapl_13893| AS27_07219| AS28_13413| CB1_000327040| D623_10008694| FLAP1| FLAP-1| FLAP (FLI LRR associated protein)| Fliiap1| FLI-LRR-associated protein 1| GC-binding factor 2| GCF-2| H186 FLAP| H920_06158| HUFI-1| I79_023832| leucine-rich repeat flightless-interacting protein 1| leucine-rich repeat flightless-interacting protein 2| leucine rich repeat (in FLII) interacting protein 1| leucine rich repeat interacting protein 1| leucine-rich repeat interacting protein-1| LRRFIP2| LRR FLII-interacting protein 1| M91_11475| M959_07757| MDA_GLEAN10026117| N300_02854| N301_01974| N302_14192| N303_04597| N305_03002| N306_11448| N307_05478| N308_06192| N309_08092| N310_02672| N311_04479| N312_13325| N322_13688| N324_12453| N325_11939| N326_12185| N327_04875| N328_01579| N330_06391| N331_06954| N332_13792| N333_05889| N334_04680| N335_02938| N336_05069| N339_03126| N340_13533| N341_08273| NEDD8-conjugating enzyme| PAL_GLEAN10006419| PANDA_015878| TAR RNA-interacting protein| TREES_T100020652| TRIP| UY3_15911| Y1Q_011132| Y956_15092| Z169_00909| lrrfip1

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