The Function of LRRFIP1
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
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Protein names
Recommended name:
Leucine-rich repeat flightless-interacting protein 1Alternative name(s):
LRR FLII-interacting protein 1GC-binding factor 2
TAR RNA-interacting protein
- RS11680012 (LRRFIP1) ??
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Top Gene-Substance Interactions
Substances That Increase LRRFIP1
| Substances | Interaction | Organism | Category |
Substances That Decrease LRRFIP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed.
Gene Pathways:
Developmental stage:
Widely expressed in fetal tissues.
Molecular Function:
- Dna Binding
- Double-Stranded Rna Binding
- Protein Homodimerization Activity
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Transcription, Dna-Templated
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Type I Interferon Production
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Nf-Kappab Transcription Factor Activity