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  3. LRRC16A

LRRC16A (Leucine rich repeat containing 16A)

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The Function of LRRC16A

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).

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LRRC16A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12526480 (LRRC16A) ??
  2. RS13217797 (LRRC16A) ??
  3. RS16890640 (LRRC16A) ??
  4. RS2274089 (LRRC16A) ??
  5. RS441460 (LRRC16A) ??
  6. RS62392365 (LRRC16A) ??
  7. RS742132 (LRRC16A) ??
  8. RS932316 (LRRC16A) ??

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • PPAR-gamma1
  • HNF-1A
  • PPAR-gamma2
  • HNF-1
  • MEF-2A
  • c-Rel

Tissue specificity:

Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.

Molecular Function:

  • Protein Complex Binding

Biological Processes:

  • Actin Filament Network Formation
  • Actin Filament Organization
  • Blood Coagulation
  • Lamellipodium Assembly
  • Macropinocytosis
  • Negative Regulation Of Barbed-End Actin Filament Capping
  • Positive Regulation Of Actin Filament Polymerization
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Stress Fiber Assembly
  • Positive Regulation Of Substrate Adhesion-Dependent Cell Spreading
  • Ruffle Organization
  • Urate Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Carmil1| F-actin-uncapping protein LRRC16A| leucine rich repeat containing 16| leucine-rich repeat-containing protein 16A| LRRC16| lrrc16a

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