The Function of LRRC16A
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).
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- RS12526480 (LRRC16A) ??
- RS13217797 (LRRC16A) ??
- RS16890640 (LRRC16A) ??
- RS2274089 (LRRC16A) ??
- RS441460 (LRRC16A) ??
- RS62392365 (LRRC16A) ??
- RS742132 (LRRC16A) ??
- RS932316 (LRRC16A) ??
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Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
Molecular Function:
Biological Processes:
- Actin Filament Organization
- Blood Coagulation
- Lamellipodium Assembly
- Positive Regulation Of Cell Migration
- Positive Regulation Of Actin Filament Polymerization
- Ruffle Organization
- Macropinocytosis
- Urate Metabolic Process
- Positive Regulation Of Stress Fiber Assembly
- Actin Filament Network Formation
- Positive Regulation Of Substrate Adhesion-Dependent Cell Spreading
- Negative Regulation Of Barbed-End Actin Filament Capping