The Function of LPXN
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
Protein names
Recommended name:
Leupaxin- RS10896794 (LPXN) ??
- RS112960054 (LPXN) ??
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Top Gene-Substance Interactions
Substances That Increase LPXN
| Substances | Interaction | Organism | Category |
Substances That Decrease LPXN
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression.
Molecular Function:
Biological Processes:
- Cell Adhesion
- Negative Regulation Of B Cell Receptor Signaling Pathway
- Negative Regulation Of Cell Adhesion
- Protein Complex Assembly
- Regulation Of Cell Adhesion Mediated By Integrin
- Regulation Of Transcription, Dna-Templated
- Signal Transduction
- Transcription, Dna-Templated