Summary of LNPEP
The gene codes for a zinc-dependent protein aminopeptidase that cleaves several hormones. The protein speeds up the conversion of angiotensingoen to angiotensin IV (AT4) and acts as a receptor for AT4 [R].
The Function of LNPEP
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Protein names
Recommended name:
Leucyl-cystinyl aminopeptidaseShort name:
IRAPAlternative name(s):
Cystinyl aminopeptidaseInsulin-regulated membrane aminopeptidase
Insulin-responsive aminopeptidase
Oxytocinase
OTase
Placental leucine aminopeptidase
P-LAP
- RS2303138 (LNPEP) ??
- RS7705093 (LNPEP) ??
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Top Gene-Substance Interactions
LNPEP Interacts with These Diseases
| Disease | Score |
Substances That Increase LNPEP
| Substances | Interaction | Organism | Category |
Substances That Decrease LNPEP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
Gene Pathways:
Cofactor:
Binds 1 zinc ion per subunit.
Molecular Function:
- Aminopeptidase Activity
- Metalloaminopeptidase Activity
- Metallopeptidase Activity
- Peptide Binding
- Zinc Ion Binding
Biological Processes:
- Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class I, Tap-Independent
- Cell-Cell Signaling
- Female Pregnancy
- Membrane Organization
- Peptide Catabolic Process
- Protein Catabolic Process
- Protein Polyubiquitination
- Proteolysis
- Regulation Of Blood Pressure
- Signal Transduction
- Smad Protein Signal Transduction