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  3. LNPEP

LNPEP (Leucyl and cystinyl aminopeptidase)

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Summary of LNPEP

The gene codes for a zinc-dependent protein aminopeptidase that cleaves several hormones. The protein speeds up the conversion of angiotensingoen to angiotensin IV (AT4) and acts as a receptor for AT4 [R].

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The Function of LNPEP

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.

Protein names

Recommended name:

Leucyl-cystinyl aminopeptidase

Short name:

IRAP

Alternative name(s):

Cystinyl aminopeptidase
Insulin-regulated membrane aminopeptidase
Insulin-responsive aminopeptidase
Oxytocinase
OTase
Placental leucine aminopeptidase
P-LAP

LNPEP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2303138 (LNPEP) ??
  2. RS7705093 (LNPEP) ??

Top Gene-Substance Interactions

LNPEP Interacts with These Diseases

Disease Score

Substances That Increase LNPEP

Substances Interaction Organism Category

Substances That Decrease LNPEP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Ik-1

Tissue specificity:

Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.

Gene Pathways:

  • Immune System
  • Membrane Trafficking
  • Renin-angiotensin system
  • Translocation of Glut4 to the Plasma Membrane

Cofactor:

Binds 1 zinc ion per subunit.

Molecular Function:

  • Aminopeptidase Activity
  • Metalloaminopeptidase Activity
  • Metallopeptidase Activity
  • Peptide Binding
  • Zinc Ion Binding

Biological Processes:

  • Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class I, Tap-Independent
  • Cell-Cell Signaling
  • Female Pregnancy
  • Membrane Organization
  • Peptide Catabolic Process
  • Protein Catabolic Process
  • Protein Polyubiquitination
  • Proteolysis
  • Regulation Of Blood Pressure
  • Signal Transduction
  • Smad Protein Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PLAP| leucyl/cystinyl aminopeptidase| CAP| IRAP| aminopeptidase Vp165| angiotensin IV receptor| AT (4) receptor| AT4 receptor| CB1_011054003| cystinyl aminopeptidase| D623_10033896| fb73h12| GP160| GW7_19511| H920_04287| insulin-regulated aminopeptidase| insulin-regulated membrane aminopeptidase| insulin-regulated membrane aminopeptidase IRAP| insulin-responsive aminopeptidase| leucyl-cystinyl aminopeptidase| M91_09098| MDA_GLEAN10017514| N305_14308| N309_05986| N324_02906| N333_02326| OTase| oxytocinase| PANDA_008320| placental leucine aminopeptidase| P-LAP| TREES_T100019054| UY3_01604| vasopressinase| vesicle protein of 165 kDa| vp165| Y1Q_029760| lnpep

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