Summary of LMOD1
The gene codes for the leiomodin 1 protein. Higher levels of this expressed protein are linked to Graves' disease and thyroid-associated ophthalmopathy [R].
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The Function of LMOD1
Mediates nucleation of actin filaments.
Protein names
Recommended name:
Leiomodin-1Alternative name(s):
64 kDa autoantigen 1D64 kDa autoantigen 1D3
64 kDa autoantigen D1
Leiomodin, muscle form
Smooth muscle leiomodin
SM-Lmod
Thyroid-associated ophthalmopathy autoantigen
- RS2819348 (LMOD1) ??
- RS2820312 (LMOD1) ??
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Top Gene-Substance Interactions
Substances That Increase LMOD1
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Substances That Decrease LMOD1
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Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in lung vascular smooth muscle (at protein level) (PubMed:27144530). Detected in thyroid and extraocular smooth muscle, but not skeletal muscle (PubMed:2026759). Detected in heart, aorta, skeletal muscle, colon, urinary bladder, uterus, stomach, and small intestine (PubMed:11318603).
Gene Pathways:
Molecular Function:
Biological Processes:
- Muscle Contraction
- Actin Filament Organization
- Myofibril Assembly
- Positive Regulation Of Actin Filament Polymerization
- Actin Nucleation
- Pointed-End Actin Filament Capping