• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. LMOD1

LMOD1 (Leiomodin 1)

Loading...

Summary of LMOD1

The gene codes for the leiomodin 1 protein. Higher levels of this expressed protein are linked to Graves' disease and thyroid-associated ophthalmopathy [R].

0 users want this gene increased, 0 users want it decreased

The Function of LMOD1

Mediates nucleation of actin filaments.

Protein names

Recommended name:

Leiomodin-1

Alternative name(s):

64 kDa autoantigen 1D
64 kDa autoantigen 1D3
64 kDa autoantigen D1
Leiomodin, muscle form
Smooth muscle leiomodin
SM-Lmod
Thyroid-associated ophthalmopathy autoantigen

LMOD1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2819348 (LMOD1) ??
  2. RS2820312 (LMOD1) ??

Top Gene-Substance Interactions

Substances That Increase LMOD1

Substances Interaction Organism Category

Substances That Decrease LMOD1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Max
  • HNF-4alpha1
  • HNF-4alpha2

Tissue specificity:

Detected in lung vascular smooth muscle (at protein level) (PubMed:27144530). Detected in thyroid and extraocular smooth muscle, but not skeletal muscle (PubMed:2026759). Detected in heart, aorta, skeletal muscle, colon, urinary bladder, uterus, stomach, and small intestine (PubMed:11318603).

Gene Pathways:

  • Muscle contraction

Molecular Function:

  • Tropomyosin Binding

Biological Processes:

  • Actin Filament Organization
  • Actin Nucleation
  • Muscle Contraction
  • Myofibril Assembly
  • Pointed-End Actin Filament Capping
  • Positive Regulation Of Actin Filament Polymerization
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| D1| 1D| 64kD| 64 kDa autoantigen 1D| 64 kDa autoantigen 1D3| 64 kDa autoantigen D1| A306_10129| AS27_05373| AS28_11291| CB1_000111023| EGK_01808| H920_14220| I79_004828| leimodin 1 (smooth muscle)| leiomodin-1| leiomodin-1-like| leiomodin 1 (smooth muscle)| leiomodin, muscle form| M91_08619| M959_10687| N300_03687| N301_08493| N303_06443| N308_02987| N309_12565| N310_00552| N311_06021| N312_05476| N320_06893| N321_11066| N324_00252| N326_07446| N327_12755| N328_07006| N329_01753| N331_06281| N332_02850| N333_07814| N334_09573| N335_09482| N336_01339| N339_05727| N340_05317| N341_12700| PAL_GLEAN10003752| PANDA_002556| SMLMOD| SM-LMOD| smooth muscle leiomodin| thyroid and eye muscle autoantigen D1 (64kD)| thyroid-associated ophthalmopathy autoantigen| TREES_T100003400| UY3_05238| Y1Q_008426| Y956_04613| Z169_04056| lmod1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved