The Function of LMCD1
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
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- RS171408 (LMCD1) ??
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Top Gene-Substance Interactions
LMCD1 Interacts with These Diseases
| Disease | Score |
Substances That Increase LMCD1
| Substances | Interaction | Organism | Category |
Substances That Decrease LMCD1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle.
Molecular Function:
Biological Processes:
- Cellular Protein Metabolic Process
- Mitophagy In Response To Mitochondrial Depolarization
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Calcineurin-Nfat Signaling Cascade
- Positive Regulation Of Defense Response To Virus By Host
- Regulation Of Cardiac Muscle Hypertrophy
- Transcription, Dna-Templated
- Xenophagy