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  3. LIPT1

LIPT1 (Lipoyltransferase 1)

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The Function of LIPT1

Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

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Protein names

Recommended name:

Lipoyltransferase 1, mitochondrial

Alternative name(s):

Lipoate biosynthesis protein
Lipoate-protein ligase
Lipoyl ligase

Top Gene-Substance Interactions

Substances That Increase LIPT1

Substances Interaction Organism Category

Substances That Decrease LIPT1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • FOXO4
  • NRF-2
  • Egr-2

Tissue specificity:

Highly expressed in skeletal muscle and heart, moderately in kidney and pancreas, and detected at lower levels in liver, brain, placenta and lung.

Molecular Function:

  • Lipoate-Protein Ligase Activity
  • Lipoyltransferase Activity
  • Transferase Activity, Transferring Acyl Groups

Biological Processes:

  • Cellular Protein Modification Process
  • Glyoxylate Metabolic Process
  • Lipid Metabolic Process
  • Protein Lipoylation

Drug Bank:

  • Lipoic Acid
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_01154| AS27_11830| AS28_11553| EG623661| fi89f05| GW7_18301| H920_13444| lipoate biosynthesis protein| lipoate-protein ligase| lipoyl ligase| lipoyltransferase 1, mitochondrial| LIPT1D| N300_03189| N301_16532| N302_15232| N305_12656| N306_09055| N307_06916| N309_14941| N320_07758| N321_04985| N322_03109| N324_04460| N328_09070| N330_10295| N333_01993| N334_07841| N341_08638| PAL_GLEAN10003476| PANDA_008686| TREES_T100005904| UY3_15777| Y1Q_014097| Y956_02763| Z169_11802| lipt1

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