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  3. LIPC

LIPC (Lipase C, hepatic type)

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Summary of LIPC

The LIPC gene encodes an enzyme called hepatic lipase. It helps with the conversion of fat-transporting molecules low-density lipoproteins and intermediate-density lipoproteins to low-density lipoproteins. They also help transport high-density lipoproteins that carry cholesterol and triglycerides from the blood to the liver (R). 

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The Function of LIPC

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Protein names

Recommended name:

Hepatic triacylglycerol lipase

Short name:

HL

Alternative name(s):

Hepatic lipase
Lipase member C

LIPC SNPs

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  1. RS1077834 (LIPC) ??
  2. RS1077835 (LIPC) ??
  3. RS11857380 (LIPC) ??
  4. RS12594375 (LIPC) ??
  5. RS12914626 (LIPC) ??
  6. RS17301739 (LIPC) ??
  7. RS1800588 (LIPC) ??
  8. RS2070895 (LIPC) ??
  9. RS261332 (LIPC) ??
  10. RS261334 (LIPC) ??
  11. RS261336 (LIPC) ??
  12. RS261342 (LIPC) ??
  13. RS3825776 (LIPC) ??
  14. RS3829462 (LIPC) ??
  15. RS4775065 (LIPC) ??
  16. RS588136 (LIPC) ??
  17. RS6083 (LIPC) ??
  18. RS8034802 (LIPC) ??

Top Gene-Substance Interactions

LIPC Interacts with These Diseases

Disease Score

Substances That Increase LIPC

Substances Interaction Organism Category

Substances That Decrease LIPC

Substances Interaction Organism Category

Advanced Summary

     age-related macular degeneration Genetics Home Reference provides information about age-related macular degeneration. hepatic lipase deficiency At least 10 mutations in the LIPC gene have been found to cause hepatic lipase deficiency. This condition leads to abnormal levels of various fats (lipids) in the bloodstream, although it is unclear whether these changes impact the risk of developing heart disease. The LIPC gene mutations that cause this condition change single protein building blocks (amino acids) in the hepatic lipase enzyme. These mutations prevent the enzyme's release from the liver or decrease its activity in the bloodstream. As a result, VLDLs and IDLs are not efficiently converted into LDLs, and HDLs carrying cholesterol and triglycerides remain in the bloodstream. It is unclear what effect this change in fat levels has on people with hepatic lipase deficiency, as some affected people develop an accumulation of fatty deposits on the artery walls (atherosclerosis) and heart disease in mid-adulthood, while others do not.

     The LIPC gene provides instructions for making an enzyme called hepatic lipase. This enzyme is produced by liver cells and released into the bloodstream where it helps with the conversion of fat-transporting molecules called very low-density lipoproteins (VLDLs) and intermediate-density lipoproteins (IDLs) to low-density lipoproteins (LDLs). The enzyme also assists in transporting molecules called high-density lipoproteins (HDLs) that carry cholesterol and triglycerides from the blood to the liver, where the HDLs deposit these fats so they can be redistributed to other tissues or removed from the body. Hepatic lipase helps to keep these fat-transporting molecules in balance by regulating the formation of LDLs and the transport of HDLs. Normally, high levels of HDL (known as "good cholesterol") and low levels of LDL (known as "bad cholesterol") are protective against heart disease.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • HNF-4alpha1
  • HNF-4alpha2

Gene Pathways:

  • Metabolic pathways
  • Glycerolipid metabolism

Molecular Function:

  • Apolipoprotein Binding
  • Heparin Binding
  • Low-Density Lipoprotein Particle Binding
  • Phospholipase Activity
  • Triglyceride Lipase Activity
  • Acylglycerol Lipase Activity
  • Heparan Sulfate Proteoglycan Binding
  • Lipid Binding
  • Lysophospholipase Activity
  • Phosphatidylcholine 1-Acylhydrolase Activity
  • Transferase Activity, Transferring Acyl Groups

Biological Processes:

  • Cholesterol Homeostasis
  • Cholesterol Metabolic Process
  • Chylomicron Remnant Clearance
  • Fatty Acid Biosynthetic Process
  • High-Density Lipoprotein Particle Remodeling
  • Intermediate-Density Lipoprotein Particle Remodeling
  • Lipid Digestion
  • Low-Density Lipoprotein Particle Remodeling
  • Phosphatidylcholine Catabolic Process
  • Reverse Cholesterol Transport
  • Triglyceride Catabolic Process
  • Triglyceride Homeostasis
  • Very-Low-Density Lipoprotein Particle Remodeling
  • Cellular Response To Hormone Stimulus
  • Chylomicron Remodeling
  • Circadian Rhythm
  • Developmental Growth
  • Glycerophospholipid Catabolic Process
  • Heparan Sulfate Proteoglycan Biosynthetic Process
  • Liver Development
  • Low-Density Lipoprotein Particle Clearance
  • Phosphatidic Acid Metabolic Process
  • Phosphatidylethanolamine Metabolic Process
  • Phosphatidylserine Metabolic Process
  • Protein Oligomerization
  • Response To Acetate
  • Response To Amino Acid
  • Response To Calcium Ion
  • Response To Carbohydrate
  • Response To Copper Ion
  • Response To Fatty Acid
  • Response To Glucocorticoid
  • Response To Hypoxia
  • Response To Magnesium Ion
  • Response To Nutrient Levels
  • Response To Peptide Hormone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_10890| Anapl_06158| AS27_14912| AS28_04211| D623_10007057| EH28_21496| H920_12605| hdlcq12| hepatic lipase| Hepatic triacylglycerol lipase| hepatic triglyceride lipase| HL| Hpl| htgl| I79_000173| lipase C| lipase, hepatic| lipase member C| liph| M91_14881| M959_05264| MDA_GLEAN10012029| N300_11934| N301_08225| N302_04905| N303_08266| N305_08053| N306_09274| N307_06518| N308_02775| N309_04870| N310_09130| N312_09130| N320_11577| N321_13171| N322_11801| N325_04635| N326_04727| N327_11380| N328_00187| N329_10762| N330_06724| N331_11543| N332_13137| N333_01243| N334_13138| N335_13085| N336_10522| N339_04220| N340_10674| N341_05851| PAL_GLEAN10023431| PANDA_019471| TREES_T100000160| Triacylglycerol lipase| UY3_03822| Y1Q_013891| Y956_05561| Z169_06652| lipc

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