Summary of LIPC
The LIPC gene codes for lipase C, also known as hepatic lipase [R].
Hepatic lipase converts very low density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) into low density lipoprotein (LDL cholesterol). It also transports high density lipoprotein (HDL cholesterol) from the blood to the liver, where fats can be processed further [R].
Hepatic lipase keeps LDL and HDL cholesterol in balance. This is important for heart health, as high LDL and low HDL increase the risk of heart disease [R].
Mutations in LDL can cause hepatic lipase deficiency. People with this condition are much more likely to have unbalanced blood cholesterol levels and may be at greater risk of atherosclerosis and heart disease [R].
Variants in LDL have also been associated with [R, R, R]:
- Problems with fat metabolism
- Age-related macular degeneration
- High cholesterol
Protein names
Recommended name:
Hepatic triacylglycerol lipaseShort name:
HLAlternative name(s):
Hepatic lipaseLipase member C
- RS1077834 (LIPC) ??
- RS1077835 (LIPC) ??
- RS11857380 (LIPC) ??
- RS12594375 (LIPC) ??
- RS12914626 (LIPC) ??
- RS17301739 (LIPC) ??
- RS1800588 (LIPC) ??
- RS2070895 (LIPC) ??
- RS261332 (LIPC) ??
- RS261334 (LIPC) ??
- RS261336 (LIPC) ??
- RS261342 (LIPC) ??
- RS3825776 (LIPC) ??
- RS3829462 (LIPC) ??
- RS4775065 (LIPC) ??
- RS588136 (LIPC) ??
- RS6083 (LIPC) ??
- RS8034802 (LIPC) ??
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Top Gene-Substance Interactions
LIPC Interacts with These Diseases
| Disease | Score |
Substances That Increase LIPC
| Substances | Interaction | Organism | Category |
Substances That Decrease LIPC
| Substances | Interaction | Organism | Category |
Advanced Summary
age-related macular degeneration Genetics Home Reference provides information about age-related macular degeneration. hepatic lipase deficiency At least 10 mutations in the LIPC gene have been found to cause hepatic lipase deficiency. This condition leads to abnormal levels of various fats (lipids) in the bloodstream, although it is unclear whether these changes impact the risk of developing heart disease. The LIPC gene mutations that cause this condition change single protein building blocks (amino acids) in the hepatic lipase enzyme. These mutations prevent the enzyme's release from the liver or decrease its activity in the bloodstream. As a result, VLDLs and IDLs are not efficiently converted into LDLs, and HDLs carrying cholesterol and triglycerides remain in the bloodstream. It is unclear what effect this change in fat levels has on people with hepatic lipase deficiency, as some affected people develop an accumulation of fatty deposits on the artery walls (atherosclerosis) and heart disease in mid-adulthood, while others do not.
The LIPC gene provides instructions for making an enzyme called hepatic lipase. This enzyme is produced by liver cells and released into the bloodstream where it helps with the conversion of fat-transporting molecules called very low-density lipoproteins (VLDLs) and intermediate-density lipoproteins (IDLs) to low-density lipoproteins (LDLs). The enzyme also assists in transporting molecules called high-density lipoproteins (HDLs) that carry cholesterol and triglycerides from the blood to the liver, where the HDLs deposit these fats so they can be redistributed to other tissues or removed from the body. Hepatic lipase helps to keep these fat-transporting molecules in balance by regulating the formation of LDLs and the transport of HDLs. Normally, high levels of HDL (known as "good cholesterol") and low levels of LDL (known as "bad cholesterol") are protective against heart disease.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Phospholipase Activity
- Lysophospholipase Activity
- Triglyceride Lipase Activity
- Heparin Binding
- Lipid Binding
- Phosphatidylcholine 1-Acylhydrolase Activity
- Transferase Activity, Transferring Acyl Groups
- Low-Density Lipoprotein Particle Binding
- Apolipoprotein Binding
- Heparan Sulfate Proteoglycan Binding
- Acylglycerol Lipase Activity
Biological Processes:
- Response To Hypoxia
- Liver Development
- Fatty Acid Biosynthetic Process
- Phosphatidylserine Metabolic Process
- Circadian Rhythm
- Cholesterol Metabolic Process
- Response To Carbohydrate
- Response To Acetate
- Heparan Sulfate Proteoglycan Biosynthetic Process
- Triglyceride Catabolic Process
- Response To Nutrient Levels
- Response To Magnesium Ion
- Cellular Response To Hormone Stimulus
- Chylomicron Remodeling
- Very-Low-Density Lipoprotein Particle Remodeling
- Intermediate-Density Lipoprotein Particle Remodeling
- Low-Density Lipoprotein Particle Remodeling
- High-Density Lipoprotein Particle Remodeling
- Chylomicron Remnant Clearance
- Low-Density Lipoprotein Particle Clearance
- Phosphatidylcholine Catabolic Process
- Cholesterol Homeostasis
- Response To Amino Acid
- Response To Peptide Hormone
- Reverse Cholesterol Transport
- Lipid Digestion
- Phosphatidylethanolamine Metabolic Process
- Phosphatidic Acid Metabolic Process
- Glycerophospholipid Catabolic Process
- Response To Copper Ion
- Developmental Growth
- Protein Oligomerization
- Response To Glucocorticoid
- Response To Calcium Ion
- Triglyceride Homeostasis
- Response To Fatty Acid