The Function of LIN7A
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Protein names
Recommended name:
Protein lin-7 homolog AAlternative name(s):
Lin-7AhLin-7
Mammalian lin-seven protein 1
MALS-1
Tax interaction protein 33
TIP-33
Vertebrate lin-7 homolog 1
Veli-1
- RS1163656 (LIN7A) ??
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Top Gene-Substance Interactions
LIN7A Interacts with These Diseases
Disease | Score |
Substances That Increase LIN7A
Substances | Interaction | Organism | Category |
Substances That Decrease LIN7A
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain, testis, kidney, placenta and liver.
Molecular Function:
Biological Processes:
- Exocytosis
- Inner Ear Development
- Maintenance Of Epithelial Cell Apical/Basal Polarity
- Neurotransmitter Secretion
- Protein Complex Assembly
- Protein Localization To Basolateral Plasma Membrane
- Protein Transport
- Synaptic Vesicle Transport