LIN7A | SelfDecode | Genome Analysis

The Function of LIN7A

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

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Protein names

Recommended name:

Protein lin-7 homolog A

Alternative name(s):

Lin-7A
hLin-7
Mammalian lin-seven protein 1
MALS-1
Tax interaction protein 33
TIP-33
Vertebrate lin-7 homolog 1
Veli-1

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RS1163656 (LIN7A) ??

Top Gene-Substance Interactions

LIN7A Interacts with These Diseases

Disease	Score

Substances That Increase LIN7A

Category:

Substances	Interaction	Organism	Category

Substances That Decrease LIN7A

Category:

Substances	Interaction	Organism	Category

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Expressed in brain, testis, kidney, placenta and liver.

Molecular Function:

L27 Domain Binding

Biological Processes:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11219| AS27_13999| AS28_00918| CB1_001195010| D623_10034132| H920_13650| LIN7| LIN-7A| lin7b| lin-7-Ba| lin 7 homolog a| lin-7 homolog A| lin-7 homolog A (C. elegans)| Lin-7-like A| lin-7-like protein A| Lin-7 like protein A| M91_15071| M959_11124| MALS-1| mammalian LIN-7 1| mammalian lin-seven protein 1| mLin-7| N300_06080| N301_14766| N302_15676| N303_14378| N305_06337| N306_10512| N307_10245| N308_02060| N309_02034| N320_12376| N324_10371| N326_07485| N328_11023| N329_05219| N330_08444| N331_06310| N332_06600| N336_01424| N340_13070| N341_07625| neuroepithelial polarity protein| PAL_GLEAN10022426| PANDA_004931| Protein lin-7 A| protein lin-7 A-like protein| protein lin-7 homolog A| protein lin-7 homolog A-like| protein lin-7-like A-like protein| Protein lin-7 like protein A| Protein lin-7-like protein A| putative protein lin-7-like protein| tax interaction protein 33| TIP-33| Veli| veli-1| VELI1| veli-1 protein| vertebrate homolog of C. elegans Lin-7 type 1| vertebrate lin-7 homolog 1| vertebrate LIN7 homolog 1| Y1Q_007643| Y956_11089| Z169_14303| lin7a

LIN7A (Lin-7 homolog A, crumbs cell polarity complex component)

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