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  3. LIMK2

LIMK2 (LIM domain kinase 2)

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The Function of LIMK2

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.

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Protein names

Recommended name:

LIM domain kinase 2

Short name:

LIMK-2

LIMK2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2106294 (LIMK2) ??
  2. RS2413045 (LIMK2) ??
  3. RS4141404 (LIMK2) ??

Top Gene-Substance Interactions

Substances That Increase LIMK2

Substances Interaction Organism Category

Substances That Decrease LIMK2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • GATA-1
  • Cdc5
  • Olf-1
  • Pax-2
  • NCX/Ncx

Tissue specificity:

Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed.

Gene Pathways:

  • Regulation of actin cytoskeleton
  • Axon guidance

Molecular Function:

  • Atp Binding
  • Protein Serine/Threonine Kinase Activity
  • Zinc Ion Binding

Biological Processes:

  • Phosphorylation
  • Spermatogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| LIMK1| AS27_09002| AS28_08527| CB1_000760024| D623_10027568| H920_14867| I79_017425| LIM domain kinase 1| LIM domain kinase 2-like protein| LIMK| LIMK-2| Limk2b| LIM kinase 2| LIM motif-containing protein kinase 2| Link2| M91_11950| M959_05974| MDA_GLEAN10018550| N300_08250| N301_16409| N302_15481| N303_08747| N306_12508| N307_14074| N308_10037| N309_13402| N310_12606| N312_09446| N320_03257| N321_07116| N322_06830| N326_08309| N328_09391| N330_08940| N331_03455| N333_04853| N335_04723| N336_02592| N340_02791| N341_03129| PAL_GLEAN10007963| PANDA_003608| protein phosphatase 1 regulatory subunit 14B pseudogene| TREES_T100017065| whe| xlimk2| Y1Q_009489| Y956_15760| Z169_14558| limk2

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