The Function of LILRA3
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.
Recommended name:Leukocyte immunoglobulin-like receptor subfamily A member 3
Alternative name(s):CD85 antigen-like family member E
Immunoglobulin-like transcript 6
Leukocyte immunoglobulin-like receptor 4
Monocyte inhibitory receptor HM43/HM31
CD antigen CD85e
Top Gene-Substance Interactions
Substances That Increase LILRA3
Substances That Decrease LILRA3
The following transcription factors affect gene expression:
Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.