The Function of LIF
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
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Protein names
Recommended name:
Leukemia inhibitory factorShort name:
LIFAlternative name(s):
Differentiation-stimulating factorD factor
Melanoma-derived LPL inhibitor
MLPLI
Emfilermin
- RS929271 (LIF) ??
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Top Gene-Substance Interactions
LIF Interacts with These Diseases
| Disease | Score |
Substances That Increase LIF
| Substances | Interaction | Organism | Category |
Substances That Decrease LIF
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Cytokine Activity
- Growth Factor Activity
- Leukemia Inhibitory Factor Receptor Binding
- Receptor Binding
- Transcription Factor Activity, Rna Polymerase Ii Transcription Factor Recruiting
Biological Processes:
- Blood Vessel Remodeling
- Decidualization
- Embryo Implantation
- Immune Response
- Leukemia Inhibitory Factor Signaling Pathway
- Lung Alveolus Development
- Lung Lobe Morphogenesis
- Lung Vasculature Development
- Multicellular Organism Development
- Muscle Organ Morphogenesis
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Hormone Secretion
- Negative Regulation Of Meiotic Nuclear Division
- Neuron Development
- Positive Regulation Of Astrocyte Differentiation
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Histone H3-K27 Acetylation
- Positive Regulation Of Macrophage Differentiation
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Peptidyl-Serine Phosphorylation Of Stat Protein
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Protein Localization To Nucleus
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
- Regulation Of Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Spongiotrophoblast Differentiation
- Stem Cell Differentiation
- Stem Cell Population Maintenance
- Trophoblast Giant Cell Differentiation
- Tyrosine Phosphorylation Of Stat3 Protein
- Retina Development In Camera-Type Eye
- Astrocyte Differentiation
- Negative Regulation Of Angiogenesis
- Positive Regulation Of Corticotropin Secretion
- Positive Regulation Of Neuron Projection Development
- Transdifferentiation