The Function of LIF
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
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Protein names
Recommended name:
Leukemia inhibitory factorShort name:
LIFAlternative name(s):
Differentiation-stimulating factorD factor
Melanoma-derived LPL inhibitor
MLPLI
Emfilermin
- RS929271 (LIF) ??
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Top Gene-Substance Interactions
LIF Interacts with These Diseases
| Disease | Score |
Substances That Increase LIF
| Substances | Interaction | Organism | Category |
Substances That Decrease LIF
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcription Factor Activity, Rna Polymerase Ii Transcription Factor Recruiting
- Receptor Binding
- Cytokine Activity
- Leukemia Inhibitory Factor Receptor Binding
- Growth Factor Activity
Biological Processes:
- Blood Vessel Remodeling
- Immune Response
- Multicellular Organism Development
- Embryo Implantation
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Positive Regulation Of Neuron Projection Development
- Negative Regulation Of Angiogenesis
- Stem Cell Population Maintenance
- Positive Regulation Of Peptidyl-Serine Phosphorylation
- Positive Regulation Of Peptidyl-Serine Phosphorylation Of Stat Protein
- Tyrosine Phosphorylation Of Stat3 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Macrophage Differentiation
- Negative Regulation Of Meiotic Nuclear Division
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Decidualization
- Negative Regulation Of Hormone Secretion
- Lung Alveolus Development
- Muscle Organ Morphogenesis
- Neuron Development
- Astrocyte Differentiation
- Positive Regulation Of Astrocyte Differentiation
- Leukemia Inhibitory Factor Signaling Pathway
- Stem Cell Differentiation
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Corticotropin Secretion
- Retina Development In Camera-Type Eye
- Transdifferentiation
- Lung Vasculature Development
- Lung Lobe Morphogenesis
- Trophoblast Giant Cell Differentiation
- Spongiotrophoblast Differentiation
- Negative Regulation Of Erk1 And Erk2 Cascade
- Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
- Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
- Positive Regulation Of Protein Localization To Nucleus
- Positive Regulation Of Histone H3-K27 Acetylation
- Regulation Of Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding