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  3. LGALS3

LGALS3 (Galectin 3)

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The Function of LGALS3

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

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Protein names

Recommended name:

Galectin-3

Short name:

L-31

Alternative name(s):

Gal-3
35 kDa lectin
Carbohydrate-binding protein 35
CBP 35
Galactose-specific lectin 3
Galactoside-binding protein
GALBP
IgE-binding protein
Laminin-binding protein
Lectin L-29
Mac-2 antigen

LGALS3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2274273 (LGALS3) ??
  2. RS4644 (LGALS3) ??
  3. RS4652 (LGALS3) ??

Top Gene-Substance Interactions

LGALS3 Interacts with These Diseases

Disease Score

Substances That Increase LGALS3

Substances Interaction Organism Category

Substances That Decrease LGALS3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • Sp1
  • AML1a

Tissue specificity:

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.

Gene Pathways:

  • Immune System

Molecular Function:

  • Carbohydrate Binding
  • Chemoattractant Activity
  • Ige Binding
  • Laminin Binding
  • Poly(A) Rna Binding

Biological Processes:

  • Eosinophil Chemotaxis
  • Epithelial Cell Differentiation
  • Innate Immune Response
  • Macrophage Chemotaxis
  • Monocyte Chemotaxis
  • Mononuclear Cell Migration
  • Mrna Processing
  • Negative Regulation Of Endocytosis
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
  • Negative Regulation Of Immunological Synapse Formation
  • Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To Mhc Molecule On Antigen Presenting Cell
  • Negative Regulation Of T Cell Receptor Signaling Pathway
  • Neutrophil Chemotaxis
  • Positive Chemotaxis
  • Positive Regulation Of Calcium Ion Import
  • Positive Regulation Of Mononuclear Cell Migration
  • Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Regulation Of T Cell Apoptotic Process
  • Regulation Of T Cell Proliferation
  • Rna Splicing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| laminin-binding protein| GBP| lectin, galactoside-binding, soluble, 3| 35 kDa lectin| A306_11380| advanced glycation end-product receptor 3| AGE-R3| AS27_14295| AS28_07705| beta-galactosides-binding lectin| carbohydrate-binding protein 35| CB1_000513017| CBP30| CBP35| CBP 35| cytogaligin| EGK_18207| epsilon BP| gal3| gal-3| galactose-specific lectin 3| GALBP| Galectin-3| galectin-3-like protein| galig| H920_08851| IgE binding protein| IgE-binding protein| L31| L-34| L-34 galactoside-binding lectin| lectin| lectin, galactose binding, soluble 3| lectin galactoside-binding soluble 3| lectin, galactoside-binding, soluble, 3 (galectin 3)| lectin galactoside-binding soluble 3 protein| lectin L-29| LGALS2| M91_04102| M959_06434| Mac-2| MAC2| mac-2 antigen| mitogaligin| N300_01595| N301_11660| N302_06493| N303_03994| N305_07353| N306_05164| N307_08503| N311_05600| N312_05278| N320_05994| N322_09405| N324_11909| N325_09274| N326_08317| N327_02910| N329_13122| N331_10260| N332_07094| N333_03408| N334_00848| N335_04754| N336_08856| N339_00930| palectin-3| PANDA_019441| TREES_T100013483| UY3_09750| Y1Q_020171| Y956_12441| Z169_07159| lgals3

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