The Function of LGALS3
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
Protein names
Recommended name:
Galectin-3Short name:
L-31Alternative name(s):
Gal-335 kDa lectin
Carbohydrate-binding protein 35
CBP 35
Galactose-specific lectin 3
Galactoside-binding protein
GALBP
IgE-binding protein
Laminin-binding protein
Lectin L-29
Mac-2 antigen
- RS2274273 (LGALS3) ??
- RS4644 (LGALS3) ??
- RS4652 (LGALS3) ??
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Top Gene-Substance Interactions
LGALS3 Interacts with These Diseases
| Disease | Score |
Substances That Increase LGALS3
| Substances | Interaction | Organism | Category |
Substances That Decrease LGALS3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
Gene Pathways:
Molecular Function:
Biological Processes:
- Monocyte Chemotaxis
- Mrna Processing
- Rna Splicing
- Neutrophil Chemotaxis
- Epithelial Cell Differentiation
- Regulation Of T Cell Proliferation
- Innate Immune Response
- Negative Regulation Of Endocytosis
- Eosinophil Chemotaxis
- Macrophage Chemotaxis
- Negative Regulation Of T Cell Receptor Signaling Pathway
- Positive Chemotaxis
- Regulation Of T Cell Apoptotic Process
- Mononuclear Cell Migration
- Positive Regulation Of Mononuclear Cell Migration
- Positive Regulation Of Calcium Ion Import
- Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
- Negative Regulation Of Immunological Synapse Formation
- Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To Mhc Molecule On Antigen Presenting Cell
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway