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  3. LGALS2

LGALS2 (Galectin 2)

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Summary of LGALS2

LGALS2 encodes a protein  that acts as a clumping molecule (lectin) for a class of sugars called beta galactosides (R). Genetic variation of a single nucleotide on one section of noncoding DNA can greatly affect the degree of the protein expression, which is related to increased risk of heart attack (R).

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The Function of LGALS2

This protein binds beta-galactoside. Its physiological function is not yet known.

Protein names

Recommended name:

Galectin-2

Short name:

HL14

Alternative name(s):

Gal-2
Beta-galactoside-binding lectin L-14-II
Lactose-binding lectin 2
S-Lac lectin 2

LGALS2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12157904 (LGALS2) ??
  2. RS7291467 (LGALS2) ??

Top Gene-Substance Interactions

LGALS2 Interacts with These Diseases

Disease Score

Substances That Increase LGALS2

Substances Interaction Organism Category

Substances That Decrease LGALS2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Myocardial infarction 1

     From NCBI Gene: The protein encoded by this gene is a soluble beta-galactoside binding lectin . The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008] From UniProt: This protein binds beta-galactoside. Its physiological function is not yet known.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AP-1
  • c-Jun
  • HNF-4alpha1
  • HNF-4alpha2
  • c-Fos

Molecular Function:

  • Carbohydrate Binding
  • Galactoside Binding
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_16085| AS27_07847| AS28_09529| beta-galactoside-binding lectin L-14-II| CB1_000175030| gal-2| Galectin-2| GW7_02554| H920_01927| HL14| I79_018535| lactose-binding lectin 2| lectin, galactose-binding, soluble 2| lectin, galactoside-binding, soluble, 2| lectin, galactoside-binding, soluble, 2 (galectin 2)| lectin, galactoside-binding, soluble, 3| LGALS3| M91_14174| M959_13978| N300_11521| N301_10198| N302_12689| N303_09885| N305_14045| N306_00911| N307_05133| N308_03255| N309_04778| N310_05754| N311_10616| N312_03023| N320_00678| N321_08025| N322_03020| N324_00567| N326_09612| N327_06857| N329_10213| N330_06174| N331_07483| N332_05020| N333_11790| N334_05350| N335_00592| N336_02831| N339_05948| N340_07777| N341_05067| PAL_GLEAN10002080| PANDA_002491| S-Lac lectin 2| Y1Q_012222| Y956_01190| Z169_12015| lgals2

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