The Function of LGALS1
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Protein names
Recommended name:
Galectin-1Short name:
HBLAlternative name(s):
Gal-114 kDa laminin-binding protein
HLBP14
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
HPL
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
Putative MAPK-activating protein PM12
S-Lac lectin 1
- RS4820294 (LGALS1) ??
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Top Gene-Substance Interactions
LGALS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase LGALS1
| Substances | Interaction | Organism | Category |
Substances That Decrease LGALS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.
Molecular Function:
Biological Processes:
- Apoptotic Process
- Cellular Response To Glucose Stimulus
- Cellular Response To Organic Cyclic Compound
- Multicellular Organismal Response To Stress
- Myoblast Differentiation
- Negative Regulation Of Cell-Substrate Adhesion
- Negative Regulation Of Neuron Projection Development
- Plasma Cell Differentiation
- Positive Regulation Of Erythrocyte Aggregation
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Viral Entry Into Host Cell
- Regulation Of Apoptotic Process
- Response To Axon Injury
- T Cell Costimulation