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  3. LGALS1

LGALS1 (Galectin 1)

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The Function of LGALS1

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.

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Protein names

Recommended name:

Galectin-1

Short name:

HBL

Alternative name(s):

Gal-1
14 kDa laminin-binding protein
HLBP14
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
HPL
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
Putative MAPK-activating protein PM12
S-Lac lectin 1

LGALS1 SNPs

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  1. RS4820294 (LGALS1) ??

Top Gene-Substance Interactions

LGALS1 Interacts with These Diseases

Disease Score

Substances That Increase LGALS1

Substances Interaction Organism Category

Substances That Decrease LGALS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • AP-1
  • c-Jun

Tissue specificity:

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Molecular Function:

  • Glycoprotein Binding
  • Lactose Binding
  • Poly(A) Rna Binding
  • Signal Transducer Activity

Biological Processes:

  • Apoptotic Process
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Organic Cyclic Compound
  • Multicellular Organismal Response To Stress
  • Myoblast Differentiation
  • Negative Regulation Of Cell-Substrate Adhesion
  • Negative Regulation Of Neuron Projection Development
  • Plasma Cell Differentiation
  • Positive Regulation Of Erythrocyte Aggregation
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Viral Entry Into Host Cell
  • Regulation Of Apoptotic Process
  • Response To Axon Injury
  • T Cell Costimulation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GAL1| L14| 14K beta-galactoside-binding lectin| 14 kDa laminin-binding protein| 14 kDa lectin| 16 kDa beta-galactoside-binding lectin| A306_16088| AS27_07850| AS28_09532| Beta-galactoside-binding lectin| beta-galactoside-binding lectin L-14-I| beta-galactoside binding protein| beta-galactoside-binding protein 14kDa| C-14| D623_10017526| gal-1| Galaptin| Galbp| galectin| Galectin-1| galectin 1a| galectin-1-like protein| galectin CG-1B| Galectin-Ia| gbl| GBP| H920_01923| HBL| HLBP14| HPL| L-14.5| Lactose-binding lectin 1| Lect14| lectin, galactose binding, soluble 1| lectin galactoside-binding soluble 1| lectin, galactoside-binding, soluble, 1| lectin, galactoside-binding, soluble, 1 (galectin 1)| LGAS1| M91_14178| M959_13975| MDA_GLEAN10009802| N300_11524| N301_10195| N302_12692| N303_09888| N305_14042| N306_00914| N307_05130| N308_03259| N309_04781| N310_07202| N320_06524| N326_00751| N327_05437| N332_04497| N335_01336| N339_05225| N340_03290| OPG-1| PAL_GLEAN10002077| PANDA_002495| putative MAPK-activating protein PM12| RL 14.5| S-Lac lectin 1| TREES_T100011262| UY3_09689| xgalectin-Ia| Y1Q_012218| Y956_01193| Z169_12018| lgals1

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