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  3. LCP2

LCP2 (Lymphocyte cytosolic protein 2)

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The Function of LCP2

Involved in T-cell antigen receptor mediated signaling.

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Protein names

Recommended name:

Lymphocyte cytosolic protein 2

Short name:

SLP76

Alternative name(s):

SH2 domain-containing leukocyte protein of 76 kDa
SLP-76 tyrosine phosphoprotein

Top Gene-Substance Interactions

Substances That Increase LCP2

Substances Interaction Organism Category

Substances That Decrease LCP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1

Tissue specificity:

Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.

Gene Pathways:

  • Immune System
  • Hemostasis
  • Natural killer cell mediated cytotoxicity
  • T cell receptor signaling pathway
  • Osteoclast differentiation
  • Fc epsilon RI signaling pathway

Biological Processes:

  • Cytokine Secretion
  • Fc-Epsilon Receptor Signaling Pathway
  • Immune Response
  • Intracellular Signal Transduction
  • Mast Cell Activation
  • Platelet Activation
  • Positive Regulation Of Protein Kinase Activity
  • T Cell Receptor Signaling Pathway
  • Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 2| 76 kDa tyrosine phosphoprotein| CB1_001327001| CG8697 gene product from transcript CG8697-RB| CG8697-PA| CG8697-PB| CP2| cuticle p. II| D623_10007907| Dmel_CG8697| DmelLcp2| gene II| H920_04469| I79_014205| II| L[[3]]CP2| Larval cuticle protein 2| LCP-2| Lcp2-PA| Lcp2-PB| lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte| lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)| lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)| lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kDa)| m1Khoe| M91_07510| MDA_GLEAN10021381| N300_13079| N307_12674| N308_13103| N326_12396| N333_12174| N340_04707| PAL_GLEAN10018873| PANDA_011973| SH2 domain-containing leukocyte protein of 76kD| SH2 domain-containing leukocyte protein of 76 kDa| SLP76| SLP-76| SLP-76 adaptor protein| SLP-76 tyrosine phosphoprotein| TREES_T100014790| twm| tyrosine phosphoprotein slp-76| Y1Q_012781| Z169_13543| lcp2

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