The Function of LCP2
Involved in T-cell antigen receptor mediated signaling.
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Protein names
Recommended name:
Lymphocyte cytosolic protein 2Short name:
SLP76Alternative name(s):
SH2 domain-containing leukocyte protein of 76 kDaSLP-76 tyrosine phosphoprotein
Top Gene-Substance Interactions
Substances That Increase LCP2
| Substances | Interaction | Organism | Category |
Substances That Decrease LCP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
Gene Pathways:
Biological Processes:
- Cytokine Secretion
- Fc-Epsilon Receptor Signaling Pathway
- Immune Response
- Intracellular Signal Transduction
- Mast Cell Activation
- Platelet Activation
- Positive Regulation Of Protein Kinase Activity
- T Cell Receptor Signaling Pathway
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway