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  3. LCP1

LCP1 (Lymphocyte cytosolic protein 1)

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The Function of LCP1

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

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Protein names

Recommended name:

Plastin-2

Short name:

LC64P

Alternative name(s):

L-plastin
Lymphocyte cytosolic protein 1
LCP-1

LCP1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS7324845 (LCP1) ??

Top Gene-Substance Interactions

Substances That Increase LCP1

Substances Interaction Organism Category

Substances That Decrease LCP1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • CUTL1
  • MEF-2A
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.

Molecular Function:

  • Actin Binding
  • Actin Filament Binding
  • Calcium Ion Binding
  • Gtpase Binding

Biological Processes:

  • Actin Crosslink Formation
  • Actin Filament Bundle Assembly
  • Actin Filament Network Formation
  • Animal Organ Regeneration
  • Extracellular Matrix Disassembly
  • Positive Regulation Of Podosome Assembly
  • Protein Kinase A Signaling
  • Regulation Of Intracellular Protein Transport
  • T Cell Activation Involved In Immune Response
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| I| 1| 65 kDa macrophage protein| Anapl_13236| AS27_04773| AS28_13744| bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))| CG11650 gene product from transcript CG11650-RB| CG11650-PA| CG11650-PB| CP1| cp64| cuticle p. I| D14Ertd310e| Dmel_CG11650| DmelLcp1| DMLCP1| EGK_09301| epididymis secretory protein Li 37| fj24b12| gene I| GW7_16592| HEL-S-37| L[[3]]CP1| Larval cuticle protein 1| lc64p| LCP-1| LCP1 lymphocyte cytosolic protein 1| Lcp1-PA| Lcp1-PB| leucocyte-specific plastin 1| L-fimbrin| LPL| L-PLASTIN| L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65)| L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)| lymphocyte cytosolic plastin 1| lymphocyte cytosolic protein 1 (L-plastin)| Lymphocyte cytosolic protein-1 (plasmin)| M959_01344| N300_11906| N301_04962| N303_02223| N305_02013| N306_06180| N307_03034| N308_04549| N309_03313| N311_04323| N322_01213| N324_03699| N325_00455| N330_12812| N332_13092| N339_09509| N340_06403| PAL_GLEAN10001106| PANDA_002962| Plastin-2| plastin 2, L| Pls2| pp65| pupal cuticle protein 27| TREES_T100021137| UY3_06064| Y1Q_025961| Y956_16128| lcp1

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