The Function of LCP1
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
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Protein names
Recommended name:
Plastin-2Short name:
LC64PAlternative name(s):
L-plastinLymphocyte cytosolic protein 1
LCP-1
- RS7324845 (LCP1) ??
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Top Gene-Substance Interactions
Substances That Increase LCP1
| Substances | Interaction | Organism | Category |
Substances That Decrease LCP1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
Molecular Function:
Biological Processes:
- Actin Crosslink Formation
- Actin Filament Bundle Assembly
- Actin Filament Network Formation
- Animal Organ Regeneration
- Extracellular Matrix Disassembly
- Positive Regulation Of Podosome Assembly
- Protein Kinase A Signaling
- Regulation Of Intracellular Protein Transport
- T Cell Activation Involved In Immune Response